西替利嗪联合布地奈德治疗小儿哮喘急性发作期的临床疗效及对患儿炎症因子和肺功能的影响

Clinical efficacy of cetirizine combined with budesonide in the treatment of children with acute exacerbation of asthma and its effect on inflammatory factors and pulmonary function

目的探讨西替利嗪联合布地奈德治疗小儿哮喘急性发作期的临床疗效及对患儿炎症因子水平和肺功能的影响。方法选取2018年8月至2020年5月本院收治的66例哮喘急性发作期患儿作为研究对象,按入院编号的单双数分为对照组和联合组,各33例。对照组予以布地奈德吸入治疗,联合组予以西替利嗪口服联合布地奈德吸入治疗,比较两组临床疗效、血清炎症因子[白细胞介素-4(IL-4)、白细胞介素-17(IL-17)、白细胞介素-22(IL-22)]水平及肺功能指标[第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、第1秒用力呼气容积占用力肺活量比值(FEV_(1)/FVC)]。结果联合组治疗总有效率为90.91%,明显高于对照组的69.70%,差异有统计学意义(P<0.05)。治疗后,联合组血清IL-4、IL-17、IL-22水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,联合组FEV_(1)、FVC、FEV1/FVC水平均高于对照组,差异有统计学意义(P<0.05)。结论西替利嗪联合布地奈德治疗哮喘急性发作期患儿效果显著,可有效降低患儿血清炎症因子水平,抑制炎症反应,改善患儿肺功能,具有临床推广价值。

Objective To investigate the clinical efficacy of cetirizine combined with budesonide in the treatment of children with acute exacerbation of asthma and its effect on inflammatory factors and pulmonary function.Methods A total of 66 children with acute exacerbation of asthma who admitted to our hospital from August 2018 to May 2020 were selected as the research subjects,and they were divided into the control group and the combined group according to the odd and even numbers of the admission numbers,with 33 cases in each group.The control group was given budesonide inhalation therapy,the combined group was given oral cetirizine combined with budesonide inhalation therapy,and the clinical efficacy,serum inflammatory factors(interleukin-4[IL-4],interleukin-17[IL-17],interleukin-22[IL-22])levels and pulmonary function indicators(forced expiratory volume in one second[FEV_(1)],forced vital capacity[FVC],forced expiratory volume in one second/forced vital capacity[FEV_(1)/FVC]).Results The total effective rate of the combined group was 90.91%,which was significantly higher than 69.70%of the control group,and the difference was statistically significant(P<0.05).After treatment,the serum levels of IL-4,IL-17 and IL-22 in the combined group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of FEV_(1),FVC,and FEV_(1)/FVC in the combined group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Cetirizine combined with budesonide has significant effect in the treatment of children with acute exacerbation of asthma,which can effectively reduce the level of serum inflammatory factors,inhibit the inflammatory response,and improve the pulmonary function of children,which has clinical promotion value.