腹腔镜胆囊切除术对急性胆囊炎患者血清淀粉酶及血清肿瘤坏死因子-α、白细胞介素-8和C反应蛋白水平的影响

Effect of laparoscopic cholecystectomy on serum amylase,serum tumor necrosis factor-α,interleukin-8 and Creactionprotein levels in patients with acute cholecystitis

目的分析腹腔镜胆囊切除术对急性胆囊炎患者血清淀粉酶及血清肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、C反应蛋白(CRP)水平的影响。方法选取2016年10月至2019年10月于本院接受治疗的80例急性胆囊炎患者作为研究对象,根据随机数字表法分为两组,每组40例。对照组予以开腹胆囊切除术治疗,实验组予以腹腔镜胆囊切除术治疗,比较两组临床疗效、血清淀粉酶、髓过氧化物酶、TNF-α、IL-8及CRP水平及安全性。结果实验组治疗总有效率为97.50%,高于对照组的85.00%(P<0.05)。术后,两组血清淀粉酶及髓过氧化物酶水平均高于术前,但实验组低于对照组(P<0.05);术后,两组血清TNF-α、IL-8、CRP水平均高于术前,但实验组低于对照组(P<0.05);实验组术后并发症发生率低于对照组(P<0.05)。结论腹腔镜胆囊切除术治疗急性胆囊炎患者疗效显著,有助于降低组织损伤,缓解炎性程度,且安全性较高,值得临床推广应用。

Objective To analyze the effect of laparoscopic cholecystectomy on serum amylase,serum tumor necrosis factor-α(TNF-α),interleukin-8(IL-8)and C-reactionprotein(CRP)levels in patients with acute cholecystitis.Methods 80 cases of acute cholecystitis patients who were treated in our hospital from October 2016 to October 2019 were selected as the research subjects,and they were divide into two groups according to the random number table method,whit 40 cases in each group.The control group were treated with open cholecystectomy,the experimental group were treated with laparoscopic cholecystectomy,the clinical efficacy,serum amylase,myeloperoxidase,TNF-α,IL-8,CRP levels and safety were compared between the two groups.Results The effective rate after treatment in the experimental group was 97.50%,which was higher than 85.00%of the control group(P<0.05).After operation,the serum amylase and myeloperoxidase levels in the two groups were higher than before surgery,but the experimental group were lower than the control group(P<0.05).After operation,the postoperative serum TNF-α,IL-8 and CRP levels in the two groups were higher than before surgery,but the experimental group were lower than the control group(P<0.05).The postoperative incidence of complications in the experimental group was lower than the control group(P<0.05).Conclusion Laparoscopic cholecystectomy has significant clinical effect on patients with acute cholecystitis,which can help to reduce tissue damage,alleviate the degree of inflammation,and has high safety,it is worthy of clinical application.