内镜下钛夹联合药物对非静脉曲张性上消化道出血的止血效果及对患者炎症反应的影响

Hemostatic effect of endoscopic titanium clamp combined with drugs on non-varicose upper digestive tract bleeding under endoscope and effect on inflammatory response of patients

目的探讨内镜下钛夹联合药物对非静脉曲张性上消化道出血的止血效果及对患者炎症反应的影响。方法回顾性分析2017年7月至2020年9月本院收治的83例非静脉曲张性上消化道出血患者的临床资料,按照治疗方式不同分为常规组(n=42)与治疗组(n=41)。常规组采用药物注射止血治疗,治疗组在常规组基础上联合内镜下钛夹止血治疗,比较两组止血效果、恢复情况及治疗前后血清炎症因子水平。结果治疗组止血总有效率为97.56%,高于常规组的83.33%(P<0.05);治疗后,治疗组输血量少于常规组,肠鸣音恢复时间及住院时间均短于常规组(P<0.05);治疗后,两组血清白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)水平均低于治疗前,且治疗组低于常规组(P<0.05);两组血清白细胞介素-10(IL-10)水平均高于治疗前,且治疗组高于常规组(P<0.05)。结论内镜下钛夹联合药物可快速抑制非静脉曲张性上消化道出血,并改善患者体内炎症因子水平,增强治疗效果,促进康复,值得临床推广应用。

Objective To investigate the hemostatic effect of endoscopic titanium clamp combined with drugs on non-varicose upper gastrointestinal bleeding under endoscope and effect on inflammatory response of patients.Methods The clinical data of 83 patients with non-varicose upper gastrointestinal bleeding admitted to our hospital from July 2017 to September 2020 were retrospectively analyzed,and they were divided into conventional group(n=42)and treatment group(n=41)according to different treatment methods,the conventional group was treated with drug injection hemostasis,and the treatment group was treated with endoscopic titanium clamp hemostasis on the basis of the conventional group,the hemostasis effect,recovery and serum inflammatory factor levels before and after treatment were compared between the two groups.Results The total effective rate of hemostasis in the treatment group was 97.56%,which was higher than 83.33%in the conventional group(P<0.05).After treatment,the blood transfusion volume in the treatment group was less than that in the conventional group,and the recovery time of intestinal sound and hospital stay were shorter than those in the conventional group(P<0.05).After treatment,the serum levels of interleukin-6(IL-6)and interleukin-1β(IL-1β)in two groups were lower than before treatment,and the treatment group was lower than the conventional group(P<0.05).Serum interleukin-10(IL-10)levels in both groups were higher than before treatment,and the treatment group was higher than the conventional group(P<0.05).Conclusion Endoscopic titanium clamp combined with drugs can rapidly stop non-varicose upper gastrointestinal bleeding,improve the level of inflammatory factors in patients,improve the therapeutic effect and promote rehabilitation,and is worthy of clinical application.