阿卡波糖联合二甲双胍治疗2型糖尿病伴高脂血症有效性和安全性的Meta分析

Meta analysis of efficacy and safety of acarbose combined with metformin in the treatment of type 2 diabetes mellitus with hyperlipidemia

目的系统评价阿卡波糖联合二甲双胍治疗2型糖尿病(T2DM)伴高脂血症的有效性和安全性,为临床治疗提供循证参考。方法计算机检索PubMed、EMBASE、维普数据库、中国知网学术文献总库、万方数字化期刊库,收集阿卡波糖联合二甲双胍治疗T2DM伴高脂血症的随机对照试验(RCT),检索时间为建库至2021年10月。由2名研究人员按照纳入及排除标准进行文献筛选、资料提取、偏倚风险评价,采用RevMan5.3软件进行Meta分析。结果本研究共纳入16篇RCT,3450例患者。Meta分析结果显示,观察组治疗前、后总胆固醇(TC)、甘油三酯(TG)水平差值均优于对照组(P<0.00001);两组的不良反应发生率无显著差异(P=0.21)。结论阿卡波糖联合二甲双胍能有效提高T2DM伴高脂血症的治疗效果,且安全性较好。

Objective To systematically evaluate the efficacy and safety of acarbose combined with metformin in the treatment of type 2 diabetes mellitus(T2DM)with hyperlipidemia,and to provide evidence-based references for clinical treatment.Methods PubMed,EMBASE,VIP database,CNKI academic literature database and Wanfang digital journal database were searched by computer,the randomized controlled trial(RCT)of acarbose combined with metformin in the treatment of T2DM with hyperlipidemia was collected.The retrieval time is from the establishment of the database to October 2021.Two researchers conducted literature screening,data extraction and bias risk assessment according to the inclusion and exclusion criteria.Meta analysis was performed using RevMan5.3 software.Results A total of 16 RCT involving 3450 patients were included in this study.The results of Meta analysis showed that the total cholesterol(TC)and triglyceride(TG)levels difference befoe and after treatment in the observation group were better than those in the control group(P<0.00001);there was no significant difference in the incidence of adverse reactions between the two groups(P=0.21).Conclusion Acarbose combined with metformin can effectively improve the therapeutic effect of T2DM with hyperlipidemia,and has good safety.