lncRNA-miRNA相关信号通路对胃癌的作用机制及中医药干预研究进展

Mechanism of lncRNA-miRNA-related Signaling Pathways in Gastric Cancer and Chinese Medicine Intervention:A Review

胃癌作为消化系统中最常见的恶性肿瘤之一,具有较高发病率和死亡率,早期临床症状不显著,大多发现后已进入进展期,大大降低了临床治愈率,严重影响患者生存质量,预后极差。近年来,随着生物信息分子领域的不断探索发现,微小核糖核酸(miRNA)和长链非编码RNA(lncRNA)作为不具备翻译能力的非编码RNA(ncRNA)而存在,并且通过作用于某一靶点,调节相关信号蛋白表达水平,从而激活或抑制某种信号通路,在胃癌进展过程中具有协助诊断、指导临床用药及判断预后的重要作用。中医药因临床疗效佳、药物不良反应少,投入临床使用易为患者所接受。着眼于当前阶段展开的一系列基础研究,以miRNA、lncRNA与信号通路之间相互作用机制作为切入点,借助中医药调控相关信号分子和信号通路的各项研究早已展开,并且经过大量实验研究数据现已证实,(1)胃癌的发生发展与miRNA、lncRNA及相关信号通路之间相互作用密不可分;(2)中医药凭借自身多靶点、多机制、多通路的优势,影响各类信号分子、信号通路,干预胃癌细胞进展。现对lncRNA、miRNA分子及主要信号通路参与胃癌发生发展过程,以及中医药调控各信号通路的具体分子机制的相关基础研究作一综述,以期结合中医药现代研究从分子水平对干预胃癌进展方面提供一定参考。

Gastric cancer(GC)is one of the most common malignant tumors in the digestive system,with high morbidity and mortality.Early clinical symptoms of GC are not obvious,and most of them have entered the advanced stage after discovery,which greatly reduces the clinical cure rate and affects the quality of life of patients,and the prognosis is very poor.In recent years,with the continuous exploration in the field of bioinformatics,it has been found that micro-RNA(miRNA)and long non-coding RNA(lncRNA)exist as noncoding RNA(ncRNA)without translation ability,and regulate the expression levels of related signal proteins by acting on a certain target,thereby activating or inhibiting a certain signaling pathway,which plays an important role in assisting diagnosis,guiding clinical medication,and judging prognosis in the progress of GC.Chinese medicine is easily accepted by patients because of its good curative effect and less side effects.In the present basic studies,with the interaction mechanism between miRNA,lncRNA and signaling pathways as the breakthrough point,various studies on the regulation of related signaling molecules and signaling pathways by Chinese medicine have been carried out.A large number of experimental data have proved that the development of GC is closely related to the interaction of miRNA,lncRNA,and related signaling pathways,and Chinese medicine,with multi-target,multi-mechanism,and multi-pathway characteristics,affects various signaling molecules and signaling pathways and intervenes in the progress of GC cells.This paper reviewed the basic research on lncRNA,miRNA molecules,and main signaling pathways involved in the occurrence and development of GC,and summarized specific molecular mechanisms of Chinese medicine in the regulation of each signaling pathway,hoping to provide references for modern research of Chinese medicine in the intervention of GC progress at the molecular level.