小檗碱抗病毒药理作用的研究进展

Research Progress in Antiviral Pharmacological Effects of Berberine

小檗碱是从中药黄连和黄柏中发现的一种异喹啉类生物碱,其具有抗病原微生物、抗炎、抗肿瘤、降血糖、调血脂、免疫抑制等药理作用,并且已经被用于心血管系统疾病、消化系统疾病、代谢性疾病、肿瘤等的临床治疗。本文主要就小檗碱对流感病毒、疱疹病毒、柯萨奇病毒B3、沙眼病毒、猪轮状病毒、乙型肝炎病毒和人免疫缺陷性病毒等的药理作用及其相关机制进行梳理总结,为小檗碱的临床应用和推广提供参考。

Berberine is an isoquinoline alkaloid found in Chinese herbs Coptidis Rhizome and Phellodendron amurense.With pharmacological effects such as anti-pathogenic microorganisms,anti-inflammation,anti-tumor,lowering blood glucose,regulating blood lipid and immunosuppression,it has been used in the clinical treatment of cardiovascular diseases,digestive diseases,metabolic diseases,tumors,etc.This article summarizes the pharmacological effects of berberine on viruses such as influenza virus,herpes virus,Coxsackie virus B3,trachoma virus,porcine rotavirus,hepatitis B virus and human immunodeficiency virus,and their related mechanisms,providing reference for the clinical application and promotion of berberine.