基于真实世界的集采中选降压药苯磺酸氨氯地平的临床使用分析

Analysis of Clinical Use of Amlodipine Besylate Tablet,a Hypotensive Drug Selected from Centralized Purchase Based on Real World

目的:分析集采中选的苯磺酸氨氯地平在临床的使用情况、临床疗效、安全性,进一步探索新形势下药学服务的新模式、新方法。方法:选取2019年11月—2021年6月在太仓市中医医院就诊的744例使用苯磺酸氨氯地平治疗的高血压患者作为研究对象,分析和评价患者的集采和非集采苯磺酸氨氯地平使用情况、临床疗效、用药安全性等。结果:患者的集采中选药换用率为82.25%,血压控制达标率为66.83%,集采中选药的药物不良反应发生率为10.62%;集采中选药的疗效和安全性与非中选药无显著差异(P>0.05);药学服务促进了集采中选药的使用,提高了用药依从性,使血压控制达标率从45.92%提高到了66.83%。结论:集采药物获得医患的认可,以药师为主体的药学服务在高血压等慢病管理中可提高药物疗效和安全性。

Objective:To analyze the clinical use,clinical efficacy and safety of amlodipine besylate tablet selected from centralized purchase,and further explore the new mode and new method of pharmaceutical services under the new situation.Methods:A total of 744 hypertensive patients treated with amlodipine besylate tablet in Taicang Traditional Chinese Medicine Hospital from November 2019 to June 2021 were selected as the research objects,and the use,clinical efficacy and medication safety of amlodipine besylate tablet of centralized purchase and non-centralized purchase were analyzed and evaluated.Results:The change rate of drugs selected from centralized purchase for patients was 82.25%,the rate of blood pressure control reaching the standard was 66.83%,and the occurrence rate of adverse drug reaction of drugs selected from centralized purchase was 10.62%.There was no significant difference in the efficacy and safety of drugs selected from centralized purchase and non-selected drugs(P>0.05).Pharmaceutical services have promoted the use of drugs selected from centralized purchase,improved medication compliance,and increased the rate of blood pressure control reaching the standard from 45.92%to 66.83%.Conclusion:Drugs selected from centralized purchase have been recognized by doctors and patients,and pharmaceutical services with pharmacists as the main body can improve drug efficacy and safety in the management of chronic diseases such as hypertension.