妊娠期凝血功能指标检测在子痫前期诊断中的效果

The Effect of Detecting Coagulation Function Indicators during Pregnancy in the Diagnosis and Treatment of Preeclampsia

目的分析妊娠期凝血功能指标检测在子痫前期诊断中的效果。方法60例子痫前期孕妇取自2020年3月至2023年3月,将其作为观察组,取同期健康孕妇60例作为对照组。检测比较两组患者的凝血功能指标,包括D-二聚体、纤维蛋白原(FIB)、凝血酶原时间(PT)、激活部分凝血活酶时间(APTT)、凝血酶原时间(TT)。根据子痫前期病情轻重将观察组孕妇划分为轻、中、重子痫前期组,并针对不同子痫前期轻重进行D-二聚体、FIB,PT、APTT、TT等指标检测比较,分析凝血功能指标和子痫前期严重性之间的相关性。结果D-二聚体、FIB水平比较,观察组显高,PT、APTT、TT水平比较,观察组显低(P<0.05);重度组D-二聚体、FIB水平均高于中度、轻度组,重度组PT、APTT、TT水平均低于轻度、中度组,组间比较差异有统计学意义(P<0.05)。应用Spearman相关性分析方法分析凝血功能指标和子痫前期孕妇病情轻重之间的相关性。结果表明D-二聚体、FIB水平与子痫前期孕妇的病情严重程度呈正相关(r=0.826、0.763,均P<0.05),而PT,APTT则呈负相关、TT水平与子痫前期孕妇的病情严重程度呈负相关(r=-0.805、-0.788、-0.814,均P<0.05)。结论子痫前期的孕妇凝血功能有凸显的异常情况,凝血功能指标如D-二聚体,FIB,PT,APTT和TT能反映出孕妇体内血液高凝状态和子痫前期的严重程度,从而为临床诊断提供了有效的依据。

Objective To analyze the effectiveness of detecting coagulation function indicators during pregnancy in the diagnosis and treatment of preeclampsia.Methods Sixty pregnant women with preeclampsia admitted to our obstetrics department from March 2020 to March 2023 were selected as the observation group,and another 60 healthy pregnant women during the same period were selected as the control group.Detect and compare coagulation function indicators such as D-dimer,fibrinogen(FIB),prothrombin time(PT),activated partial thromboplastin time(APTT),and thrombin time(TT)in two groups;According to the severity of preeclampsia,the observation group of pregnant women was divided into mild,moderate,and severe preeclampsia groups.D-dimer,FIB,PT,APTT,TT,and other coagulation function indicators of different preeclampsia severity levels were tested and compared,and the correlation between coagulation function indicators and the severity of preeclampsia was analyzed.Results The levels of D-dimer and FIB in the observation group were significantly higher than those in the control group,while the levels of PT,APTT,and TT were significantly lower than those in the control group(P<0.05).The levels of D-dimer and FIB in the severe group were higher than those in the moderate and mild groups,and the levels of PT,APTT and TT in the severe group were lower than those in the mild and moderate groups(P<0.05).Spearman's correlation analysis was applied to analyze the correlation between coagulation indices and the severity of the condition in pregnant women with preeclampsia.The levels of D-dimer and FIB were positively correlated with the severity of preeclampsia in pregnant women(r=0.826,0.763,all P<0.05),while the levels of PT,APTT,and TT were negatively correlated with the severity of preeclampsia in pregnant women(r=-0.805,-0.788,-0.814,all P<0.05).Conclusion There are significant abnormalities in the coagulation function of pregnant women with preeclampsia.D-dimer,FIB,PT,APTT,TT and other coagulation function indicators can reflect the hypercoagulable state of blood in the pregnant woman's body,and can also reflect the severity of preeclampsia in pregnant women,providing effective basis for clinical treatment.