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拔罐发泡疗法联合雷火灸治疗支气管哮喘冷哮证的疗效及对炎症因子、抗氧化活性酶的影响 被引量:3

Efficacy of Cupping-Induced Therapy Combined with Thunder-Fire Moxibustion in Treating Bronchial Asthma of Cold Syndrome and Its Influence to Inflammatory Factors and Antioxidant Enzymes
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摘要 目的:观察拔罐发泡疗法联合雷火灸对支气管哮喘冷哮证患者中医症候、炎症因子以及抗氧化活性酶的影响。方法:将76例符合纳入标准的支气管哮喘冷哮证患者随机分为对照组和治疗组,各38例,对照组采用西医常规基础治疗,治疗组在对照组基础上加用拔罐发泡联合雷火灸疗法进行治疗,两组均以7 d为1个疗程,连续治疗两个疗程。对比观察治疗前后两组患者中医症候积分、炎症因子IL-6、IL-8、TNF-α及抗氧化活性酶GSH-Px与SOD的表达变化,并进行疗效评价。结果:对照组总有效率为73.68%(28/38),治疗组总有效率为81.58%(31/38),两组比较差异具有统计学意义(P<0.05);治疗后两组中医症候各项中医症候积分均较治疗前下降(P<0.05),与对照组比较,治疗组除肺部哮鸣音外,喘促、胸闷、喉中痰鸣及咯痰4项积分下降幅度均优于对照组(P<0.05);两组治疗后炎症因子IL-6、IL-8及TNF-α表达水平均较治疗前下降(P<0.05),且治疗组下降幅度优于对照组(P<0.05);治疗后两组抗氧化活性酶GSH-Px、SOD表达水平均较治疗前上升(P<0.05),且治疗组上升幅度优于对照组(P<0.05)。结论:拔罐发泡疗法联合雷火灸可在西医药物治疗基础上。进一步改善支气管哮喘冷哮证患者的中医症候,调节炎症因子表达,抑制氧化应激。 Objective:To observe the effects of cupping-induced blistering therapy combined with thunder-fire moxibustion on clinical efficacy,inflammatory factors and antioxidant enzymes in treating bronchial asthma of cold syndrome.Methods:A total of 76 patients with bronchial asthma of cold syndrome,who met the inclusion criteria,were randomly divided into the control group and the treatment group,with 38 cases in each group.The control group was treated with conventional Western medicine;on which basis,the treatment group was also treated with cupping-induced blistering therapy combined with thunder-fire moxibustion.The two groups were treated for 2 courses of 14 days in total.The expression changes of TCM symptom scores,inflammatory factors of IL-6,IL-8 and TNF-α,as well as antioxidant enzymes of GSH-Px and SOD were compared between before and after the treatment in the two groups.Clinical efficacy was also compared between the two groups.Results:The total effective rate of the treatment group was 73.68%(28/38),which was significantly higher than 81.58%(31/38)of the control group(P<0.05).The TCM symptom scores were decreased after the treatment compared with those before the treatment in the two groups(P<0.05);the decreases in the scores of shortness of breath,chest tightness,phlegm in the throat and expectoration were more significant in the treatment group than those in the control group(P<0.05).The expressions of inflammatory factors of IL-6,IL-8 and TNF-αwere decreased after the treatment compared with those before the treatment in the two groups(P<0.05);the decreases in the treatment group were more significant than those in the control group(P<0.05).The expressions of antioxidant enzymes of GSH-Px and SOD were increased after the treatment compared with those before the treatment(P<0.05);the increases of the treatment group were more significant than those of the control group(P<0.05).Conclusion:Cupping-induced blistering therapy combined with thunder-fire moxibustion can further improve the TCM symptoms of bronchial asthma patients with cold syndrome on the basis of Western medicine treatment,it can regulate the expressions of inflammatory factors,and inhibit oxidative stress.
作者 陶继恩 TAO Jien(The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530001,China)
出处 《针灸临床杂志》 2023年第6期17-21,共5页 Journal of Clinical Acupuncture and Moxibustion
基金 广西壮族自治区中医药管理局自筹经费科研课题,编号:GZZC2020056。
关键词 拔罐发泡疗法 雷火灸 支气管哮喘 冷哮证 炎症因子 抗氧化活性酶 Cupping-induced blistering therapy Thunder-fire moxibustion Bronchial asthma Asthma of cold syndrome Inflammatory factors Antioxidant active enzymes
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