电针对2型糖尿病胃轻瘫患者胃肠激素及氧化应激的影响

Effect of EA on Gastrointestinal Hormones and Oxidative Stress in T2DM Patients with Gastroparesis

目的:探讨电针对2型糖尿病(T2DM)胃轻瘫患者胃肠激素及氧化应激的影响。方法:选取本院2019年12月--2020年12月收治的T2DM胃轻瘫患者80例,随机数字表法分为观察组与对照组,对照组α硫辛酸治疗,观察组加用足三里、中脘电针治疗,比较两组临床疗效、血糖、胃肠激素、氧化应激水平以及不良反应情况。结果:治疗后观察组临床总有效率显著高于对照组,差异有统计学意义(P<0.05);两组治疗后空腹、餐后2 h血糖较治疗前均显著降低,差异有统计学意义(P<0.05),治疗后两组间空腹、餐后2 h血糖差异无统计学意义(P>0.05);治疗后两组胃动素(MTL)、胃泌素(GAS)水平均明显下降,生长抑素(SS)水平明显上升(P<0.05),观察组治疗后MTL、GAS低于对照组,SS高于对照组(P<0.05);治疗后两组谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)水平均明显上升,活性氧类物质(ROS)水平明显下降,差异有统计学意义(P<0.05),观察组治疗后GSH-Px、SOD高于对照组,ROS低于对照组(P<0.05);两组不良反应均较少,差异无统计学意义(P>0.05)。结论:加用足三里、中脘电针治疗T2DM胃轻瘫患者相较于仅使用常规西药能够明显增强疗效,改善患者的胃肠激素及氧化应激水平,该疗法值得临床推广。

Objective:To explore the effect of electro-acupuncture(EA)on gastrointestinal hormones and oxidative stress in treatment of type 2 diabetes mellitus(T2DM)with gastroparesis.Methods:80 T2DM patients with gastroparesis were randomly divided into the observation group(n=40)and the control group(n=40).The control group was treated withαZinc Sulfate;on which basis,the observation group was also treated with electro-needling Zusanli(ST36)and Zhongwan(RN12).Clinical efficacy,blood glucose,gastrointestinal hormones,oxidative stress level and adverse reactions were compared between the two groups.Results:The total clinical effective rate of the observation group was significant higher than that of the control group(P<0.05).The fasting blood glucose and 2h postprandial blood glucose were significantly lower after the treatment than those before the treatment in the two groups(P<0.05),and in which there was no statistical differences between the two groups after the treatment(P>0.05).The levels of motilin(MTL)and gastrin(GAS)were significantly decreased,and the level of somatostatin(SS)was significantly increased after the treatment in the two groups(P<0.05);of which the improvements were more significant in the observation group(P<0.05).The levels of glutathione peroxidase(GSH-Px)and superoxide dismutase(SOD)were significantly increased,and the level of reactive oxygen species(ROS)was significantly decreased after the treatment in the two groups(P<0.05);the levels of GSH-Px and SOD were higher,and the level of ROS was lower in the observation group than those in the control group after the treatment(P<0.05).There were few adverse reactions in both groups,in which there was no statistical difference between the two groups(P>0.05).Conclusion:Electro-needling ST36 and RN12 on the basis ofαZinc Sulfate can significantly enhance the curative effect,significantly improve the gastrointestinal hormones and the oxidative stress level in treatment of T2DM with gastroparesis,which is superior to the single use ofαZinc Sulfate and is worthy of clinical promotion.