OCTA在糖尿病视网膜微血管病变中的应用价值

Application of OCTA in diabetic retinal microangiopathy

糖尿病性视网膜病变(DR)是糖尿病最常见的微血管并发症,早期不加以干预可致盲。光学相干断层扫描血管成像(OCTA)具有无创、快速、安全、高分辨率的特点,可在不同层面观察和量化分析视网膜脉络膜血管的变化情况。本文将综述OCTA的基本原理及其在DR中微动脉瘤、视网膜内微血管异常、新生血管、糖尿病脉络膜病变及糖尿病性神经损伤的应用,了解DR不同的形态学改变,实现对DR的早期筛查、监测及评估治疗效果。

Diabetic retinopathy(DR)is the most common microvascular complication of diabetes mellitus,It can cause blindness without early intervention.Optical coherence tomography angiography(OCTA)has been featured by non-invasiveness,fastness,safeness and high resolution,which can observe and analyze quantitatively the changes of retinal and choroidal vessels at different levels.In this paper,the basic principle of OCTA and its application in microaneurysms,intraretinal microvascular abnormalities,neovascularization,diabetic choroidopathy and diabetic neuronal injury of DR have been reviewed,to understand the different morphological changes of DR,and to realize the early screening,monitoring and evaluation of the treatment effect of DR.