曲美他嗪联合米力农注射液治疗高血压性心脏病伴慢性心力衰竭患者的效果

Effects of Trimetazidine combined with Milrinone injection on patients with hypertensive heart disease and chronic heart failure

目的:观察曲美他嗪联合米力农注射液治疗高血压性心脏病伴慢性心力衰竭患者的效果。方法:选取2017年3月至2021年3月该院收治的138例高血压性心脏病伴慢性心力衰竭患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各69例。对照组给予米力农注射液治疗,观察组在对照组基础上联合曲美他嗪治疗,比较两组临床疗效、治疗前后心功能指标[左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF)、左心室舒张末期容积指数(LVEDVI)、左心室收缩末期容积指数(LVESVI)]水平、运动耐量指标[最大耗氧量(VO2 Max)、无氧阈值(AT)、6分钟步行距离(6MWD)、运动时间(MT)]水平及不良反应发生率。结果:观察组治疗总有效率为91.30%,高于对照组的78.26%,差异有统计学意义(P<0.05);治疗后,观察组LVEDD、LVESD、LVEDVI、LVESVI水平均低于对照组,LVEF水平高于对照组,差异有统计学意义(P<0.05);治疗后,观察组VO2Max、AT、6MWD、MT水平均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:曲美他嗪联合米力农注射液治疗高血压性心脏病伴慢性心力衰竭患者可提高治疗总有效率和运动耐量指标水平,以及改善心功能指标水平,效果优于单纯米力农注射液治疗。

Objective:To observe effects of Trimetazidine combined with Milrinone injection in treatment of patients with hypertensive heart disease and chronic heart failure.Methods:A prospective study was conducted on 138 patients with hypertensive heart disease and chronic heart failure admitted to the hospital from March 2017 to March 2021.They were divided into control group and observation group according to the random number table method,69 cases in each.The control group was treated with Milrinone injection,while the observation group was treated with Trimetazidine on the basis of that of the control group.The clinical efficacy,the cardiac function index levels before and after the treatment[left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF),left ventricular end-diastolic volume index(LVEDVI),left ventricular end-systolic volume index(LVESVI)],the exercise tolerance index levels[maximum oxygen consumption(VO2 Max),anaerobic threshold(AT),6-minute walking distance(6MWD),exercise time(MT)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 91.30%,which was higher than 78.26%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of LVEDD,LVESD,LVEDVI and LVESVI in the observation group were lower than those in the control group,the level of LVEF was higher than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of VO2 Max,AT,6MWD and MT in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Trimetazidine combined with Milrinone injection in the treatment of the patients with hypertensive heart disease and chronic heart failure can improve the total effective rate of treatment,the levels of exercise tolerance indexes,and the levels of cardiac function indexes.Moreover,it is superior to single Milrinone injection treatment.