定坤丹联合克罗米芬治疗肾虚型PCOS不孕症患者的效果

Effects of Dingkundan combined with Clomiphene in treatment of infertility patients with PCOS of kidney deficiency type

目的:观察定坤丹联合克罗米芬治疗肾虚型多囊卵巢综合征(PCOS)不孕症患者的效果。方法:选取2018年6月至2021年6月该院收治的92例肾虚型PCOS不孕症患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各46例。对照组给予克罗米芬治疗,研究组在对照组基础上联合定坤丹治疗,比较两组临床疗效,子宫内膜厚度、成熟卵泡数量、卵泡直径,周期排卵率、周期妊娠率、累积妊娠率、治疗前后性激素指标[睾酮、卵泡雌激素(FSH)、雌二醇(E_(2))、黄体生成素(LH)、抗苗勒管激素(AMH)]水平及不良反应发生率。结果:研究组治疗总有效率为95.65%,高于对照组的80.43%,差异有统计学意义(P<0.05);治疗后,研究组子宫内膜厚度、卵泡直径、成熟卵泡数量水平均高于对照组,差异有统计学意义(P<0.05);研究组周期排卵率、周期妊娠率、累积妊娠率均高于对照组,差异有统计学意义(P<0.05);研究组睾酮、E_(2)、LH、AMH水平均低于对照组,FSH水平均高于对照组,差异有统计学意义(P<0.05);两组治疗期间均未见严重不良反应。结论:定坤丹联合克罗米芬治疗肾虚型PCOS不孕症患者,可提高临床疗效,改善子宫内内膜厚度和性激素指标水平,促进排卵,其效果优于单纯克罗米芬治疗。

Objective:To observe effects of Dingkundan combined with Clomiphene in treatment of infertility patients with polycystic ovary syndrome(PCOS)of kidney deficiency type.Methods:A prospective study was conducted on 92 infertility patients with PCOS of kidney deficiency type admitted to the hospital from June 2018 to June 2021.According to the random number table method,they were divided into control group and observation group,46 cases in each group.The control group was treated with Clomiphene,while the study group was treated with Dingkundan on the basis of that of the control group.The clinical efficacy,the endometrial thickness,the number of mature follicles,the follicle diameter,the periodic ovulation rate,the periodic pregnancy rate,the cumulative pregnancy rate,the sex hormone index levels[testosterone,follicle estrogen(FSH),estradiol(E_(2)),luteinizing hormone(LH),the anti-Mullerian hormone(AMH)],and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the study group was 95.65%,which was higher than 80.43%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the endometrial thickness,the follicle diameter,and the number of mature follicles in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The periodic ovulation rate,the periodic pregnancy rate and the cumulative pregnancy rate in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of testosterone,E_(2),LH and AMH in the study group were lower than those in the control group,the level of FSH was higher than that in the control group,and the differences were statistically significant(P<0.05).No serious adverse reactions were found in the two groups during the treatment.Conclusions:Dingkundan combined with Clomiphene in the treatment of infertility patients with PCOS of kidney deficiency can improve the clinical efficacy,improve the endometrial thickness and the sex hormone levels,and promote the ovulation.Moreover,it is superior to single Clomiphene treatment.