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复方丹参注射液联合右旋糖酐40治疗妊娠晚期特发性临界羊水过少的效果

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摘要 目的 观察复方丹参注射液联合右旋糖酐40治疗妊娠晚期特发性临界羊水过少的效果。方法 回顾性选取2021年3月—2022年3月麻城市人民医院收治的妊娠晚期特发性临界羊水过少患者63例,根据用药不同分为维生素组(n=30)和丹参组(n=33)。维生素组患者予以维生素C注射液联合右旋糖酐40,丹参组患者予以复方丹参注射液联合右旋糖酐40。2组均治疗2~3疗程,每疗程7 d。比较2组治疗效果、母婴结局、血黏度指标、羊水指数(AFI)、最大羊水池深度(AFD)、脐动脉收缩末期最大血流速度/舒张末期最小血流速度(脐动脉S/D值)。结果丹参组总有效率为96.97%,高于维生素组的76.67%(χ^(2)=4.155,P=0.042)。2组产后出血发生率、胎儿宫内窘迫发生率、新生儿窒息发生率、围生儿存活率比较,差异无统计学意义(P>0.05);丹参组剖宫产率低于维生素组,新生儿出生后5 min Apgar评分高于维生素组(P<0.01)。治疗后,2组血小板黏附率、血浆黏度低于治疗前,且丹参组低于维生素组(P<0.01)。治疗后,2组AFI、AFD、脐动脉S/D值高于治疗前,且丹参组高于维生素组(P<0.05或P<0.01)。结论 复方丹参注射液联合右旋糖酐40治疗妊娠晚期特发性临界羊水过少可增加羊水量,降低血黏度,改善脐动脉血液流变学,从而改善母婴结局。
作者 马达 董雪娜
出处 《临床合理用药杂志》 2023年第15期125-127,共3页 Chinese Journal of Clinical Rational Drug Use
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