间苯三酚注射液与氢溴酸山莨菪碱注射液治疗急诊老年痉挛性腹痛的临床效果比较

Comparison of clinical effects of phloroglucinol injection and anisodamine hydrobromide injection in the treatment of elderly spastic abdominal pain in emergency

目的比较间苯三酚注射液与氢溴酸山莨菪碱注射液治疗急诊老年痉挛性腹痛的临床效果。方法选取2020年1月—2022年6月岑溪市人民医院诊治的急诊老年痉挛性腹痛患者80例,根据随机数字表法分为观察组和对照组,每组40例。观察组患者采用间苯三酚注射液治疗,对照组患者采用氢溴酸山莨菪碱注射液治疗,2组均连续治疗3 d。比较2组患者临床症状消失时间,治疗前与治疗后30 min、1 h及3 h视觉模拟评分法(VAS)评分,治疗前后血压、生活质量评分及不良反应。结果观察组患者恶心呕吐、腹痛消失时间均短于对照组(P<0.01)。治疗后30 min、1 h及3 h,2组患者VAS评分均逐渐降低,且观察组治疗后各时点VAS评分低于对照组(P均<0.01)。治疗3 d后,2组患者收缩压与舒张压较治疗前下降,且观察组低于对照组(P均<0.01);2组患者躯体功能、行为功能、情感健康及社会功能评分较治疗前升高,且观察组高于对照组(P均<0.01)。观察组不良反应总发生率为5.00%,低于对照组的22.50%(χ^(2)=5.165,P=0.023)。结论间苯三酚注射液治疗急诊老年痉挛性腹痛的临床效果更好,患者症状消失更快,疼痛指数更低,且用药安全性高,值得临床推广应用。

Objective To compare the clinical effect of phloroglucinol injection and anisodamine hydrobromide injection in the treatment of elderly spastic abdominal pain in emergency.Methods From January 2020 to June 2022,eighty elderly patients with spasmodic abdominal pain in emergency were treated in the People′s Hospital of Cenxi City.They were randomly divided into the observation group and the control group,40 cases in each group.The observation group was treated with phloroglucinol injection,and the control group was treated with anisodamine hydrobromide injection.Both groups were treated continuously for 3 days.The time of symptom disappearance,the visual analogue scale(VAS)scores before and after treatment at 30 minutes,1 hour,and 3 hours,as well as the blood pressure,quality of life scores before and after treatment,and adverse reactions were compared.Results The disappearance time of nausea,vomiting,and abdominal pain in the observation group was shorter than that in the control group(P<0.01);At 30 minutes,1 hour,and 3 hours after treatment,the VAS scores of both groups of patients gradually decreased,and the VAS scores of the observation group were lower than those of the control group at all time points after treatment(all P<0.01);After 3 days of treatment,the systolic and diastolic blood pressure of the two groups of patients decreased compared to before treatment,and the observation group was lower than the control group(all P<0.01);After 3 days of treatment,the physical function,behavioral function,emotional health,and social function scores of the two groups of patients increased compared to before treatment,and the observation group was higher than the control group(all P<0.01);The total incidence of adverse reactions in the observation group was 5.00%,lower than 22.50%in the control group(χ^(2)=5.165,P=0.023).Conclusion The clinical effect of phloroglucinol injection in the treatment of elderly spastic abdominal pain in emergency is better,the symptoms of patients disappear faster after treatment,the pain index is lower,and the drug safety is higher,so it is recommended to promote the use of this treatment in clinical practice.