外泌体在颅脑损伤中的研究进展

Research progress of exosomes in traumatic brain injury

颅脑损伤(TBI)的致死率、致残率均较高,预后差,给患者及家庭乃至社会都带来极大的经济负担。由于计算机断层扫描、磁共振及格拉斯哥昏迷指数等都存在各自的缺陷,如何准确评估TBI的严重程度一直以来都困扰着临床。外泌体作为细胞间通信工具,广泛参与了调控多种神经系统疾病。由于其免疫原性低、循环半衰期长、能穿过脑血屏障,故有望成为诊断TBI的生物标志物及治疗TBI的特异性靶点。

Traumatic brain injury(TBI)has high fatality rate,disability rate and poor prognosis,which brings great economic burden to the patients,their families and even the society.Because CT,MRI and Grasgow coma index have their own shortcomings,how to accurately assess the severity of TBI has been bothering the clinic for a long time.As an intercellular communication tool,exosomes are widely involved in the regulation of various neurological diseases.Due to its low immunogenicity,long circulatory half-life period and ability to cross the brain-blood barrier,it is expected to be a biomarker for the diagnosis of TBI and a specific target for the treatment of TBI.