盐酸米诺环素软膏联合替硝唑治疗牙周炎的疗效及对患者牙周指数的影响

Efficacy of minocycline hydrochloride ointment combined with tinidazole in the treatment of periodontitis and its impact on patients periodontal index

目的观察盐酸米诺环素软膏联合替硝唑治疗牙周炎的疗效及对患者牙周指数的影响。方法选取2020年8月—2021年8月在辽宁省健康产业集团沈煤总医院接受治疗的牙周炎患者95例,采用随机数字表法分为观察组(n=48)和对照组(n=47)。对照组给予盐酸米诺环素软膏联合甲硝唑治疗,观察组给予盐酸米诺环素软膏联合替硝唑治疗,2组患者均治疗4周。比较2组患者临床疗效,治疗前后牙周指数[牙周袋深度(PD)、牙龈出血指数(GI)、牙周附着水平(PAL)及菌斑指数(PLI)]、炎性因子[白介素-6(IL-6)、超敏C反应蛋白(hs-CRP)及转化生长因子-β(TGF-β)]水平及不良反应。结果观察组患者总有效率为95.83%,高于对照组的80.85%(χ^(2)=5.207,P=0.023)。治疗4周后,2组患者PD、GI、PAL及PLI均低于治疗前,且观察组低于对照组(P<0.01);2组患者IL-6、hs-CRP均低于治疗前,TGF-β水平均高于治疗前,且观察组降低/升高幅度大于对照组(P<0.01);观察组患者不良反应总发生率为8.33%,低于对照组的23.40%(χ^(2)=4.057,P=0.044)。结论盐酸米诺环素软膏联合替硝唑治疗牙周炎可有效减少患者牙周菌斑,缓解炎性反应,降低不良反应发生率,进一步提高治疗效果。

Objective To observe the efficacy of minocycline hydrochloride ointment combined with tinidazole in the treatment of periodontitis and the impact on periodontal index.Methods 95 patients with periodontitis who received treatment in Shenyang Coal General Hospital of Liaoning Health Industry Group from August 2020 to August 2021 were selected and divided into observation group(n=48)and control group(n=47)by random number table method.The control group was treated with minocycline hydrochloride ointment combined with metronidazole,and the observation group was treated with minocycline hydrochloride ointment combined with tinidazole,both groups were treated for 4 weeks.Clinical curative effect,before and after the treatment of periodontal index[periodontal pocket depth(PD),gingival bleeding index(GI),periodontal attachment levels(PAL)and plaque index(PLI)],inflammatory factor[interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP)and transforming growth factor-β(TGF-β)]levels and adverse reactions of the two groups were compared.Results The total effective rate of observation group was 95.83%,higher than 80.85%of control group(χ^(2)=5.207,P=0.023).After 4 weeks of treatment,the PD,GI,PAL and PLI in 2 groups were lower than before treatment,and observation group was lower than control group(P<0.01);The IL-6,hs-CRP were lower than before the treatment,TGF-βlevels were higher than before treatment,and the decrease/increase in the observation group were greater than those in the control group(P<0.01).The total incidence of adverse reactions in observation group was 8.33%,lower than 23.40%of control group(χ^(2)=4.057,P=0.044).Conclusion Minocycline hydrochloride ointment combined with tinidazole in the treatment of periodontitis can effectively reduce periodontal plaque,relieve inflammatory reaction,reduce the incidence of adverse reactions,and further improve the therapeutic effect.