阿托伐他汀钙联合前列地尔治疗糖尿病肾病的疗效及对患者脂代谢的影响

Effect of atorvastatin calcium combined with alprostadil in the treatment of diabetes nephropathy and its effect on lipid metabolism

目的观察阿托伐他汀钙联合前列地尔治疗糖尿病肾病的疗效及对患者脂代谢的影响。方法回顾性分析2019年4月—2021年5月陕西省第二人民医院收治的糖尿病肾病患者69例的临床资料,按照治疗方法不同分为研究组35例和对照组34例。对照组给予前列地尔注射液治疗,研究组患者在对照组的基础上联合阿托伐他汀钙治疗。比较2组患者临床疗效,治疗前后肾功能指标、脂代谢指标及不良反应。结果研究组患者总有效率为94.29%,高于对照组的76.47%(χ^(2)=4.417,P=0.036);治疗后,2组患者血肌酐、尿素氮及胱抑素C(CysC)水平均较治疗前下降,且研究组低于对照组(P<0.05或P<0.01);治疗后,2组患者总胆固醇(TC)、三酰甘油(TG)及低密度脂蛋白胆固醇(LDL-C)水平明显下降,且研究组低于对照组(P<0.01)。研究组与对照组患者不良反应总发生率比较差异无统计学意义(2.86%vs.5.88%,χ^(2)=0.380,P=0.538)。结论阿托伐他汀钙联合前列地尔治疗糖尿病肾病的疗效较好,可改善肾功能及血脂水平,且安全性尚可,值得临床推荐使用。

Objective To observe the therapeutic effect of atorvastatin calcium combined with alprostadil in the treatment of diabetes nephropathy and its effect on lipid metabolism.Methods Retrospective analysis was made on the clinical data of 69 patients with diabetes nephropathy admitted to the Second People′s Hospital of Shaanxi Province from April 2019 to May 2021.According to different treatment methods,they were divided into the study group of 35 cases and the control group of 34 cases.The patients in the control group were treated with alprostadil injection,and the patients in the study group were treated with atorvastatin calcium on the basis of the control group.The clinical efficacy,renal function index,lipid metabolism index before and after treatment and adverse reactions of the two groups were compared.Results The total effective rate of patients in the study group was 94.29%,higher than 76.47%in the control group(χ^(2)=4.417,P=0.036);After treatment,the levels of serum creatinine,urea nitrogen and cystatin C(CysC)in the two groups decreased compared with those before treatment,and the study group were lower than the control group(P<0.05 or P<0.01);After treatment,the levels of total cholesterol(TC),triacylglycerol(TG)and low density lipoprotein cholesterol(LDL-C)in the two groups decreased significantly,and the study group were lower than the control group(P<0.01).There was no statistically significant difference in the total incidence of adverse reactions between the study group and the control group(2.86%vs.5.88%,χ^(2)=0.380,P=0.538).Conclusion Atorvastatin calcium combined with alprostadil injection has a significant effect in the treatment of diabetic nephropathy,and can improve renal function and blood lipid levels,and is safe.It is worthy of clinical recommendation.