事件相关电位P300在儿童神经系统疾病伴认知障碍中的研究进展

Progress of event-related potential P300 in children with neurological diseases and cognitive impairment

儿童神经系统疾病可以引起大脑结构及功能异常,常伴随认知障碍,对其智力发育、社会生活产生巨大影响,因此早期评估认知功能显得尤为重要。事件相关电位P300是临床上一种重要的电生理技术,相较于其他评估方式,具备客观、可重复、无创的优点。P300在评估儿童神经系统疾病伴认知障碍时具有良好的效果,为临床诊疗及预后提供参考依据。该文就P300在儿童常见神经系统疾病伴认知障碍中的研究进展作一综述,旨在提高临床工作者对其的认识。

Children′s neurological diseases can cause problems in structure and function of the brain,which is often accompanied by cognitive impairment.They have a great influence on children′s intellectual development and social life,so assessing cognitive function earlier is particularly significant.Event-related potential(ERP)P300 is an important electrophysiological technique in clinical practice.Compared with other evaluation methods,P300 has the advantages of objective,repeatable and non-invasive.P300 has a good effect in the assessment of children with neurological diseases and cognitive impairment,which provides a reference for clinical diagnosis,treatment and prognosis.This article reviews the research progress of P300 in children with common neurological diseases and cognitive impairment,in order to improve the understanding of clinical workers.