拉贝洛尔对重度子痫前期患者血压、24 h尿蛋白水平及分娩结局的影响

Effect of labetalol on blood pressure,24-h urinary protein level and delivery outcome in patients with severe preeclampsia

目的分析重度子痫前期患者接受拉贝洛尔治疗对其血压、24 h尿蛋白水平和分娩结局的影响。方法60例重度子痫前期患者,根据入院顺序分为对照组和研究组,每组30例。两组患者均给予常规治疗,在此基础上,对照组患者配合硝苯地平治疗,研究组患者配合拉贝洛尔治疗。比较两组患者血压、24 h尿蛋白水平和不良分娩结局情况。结果研究组患者收缩压、舒张压及24 h尿蛋白水平分别为(139.27±13.68)mm Hg(1 mm Hg=0.133 kPa)、(84.02±6.94)mm Hg、(2670.66±42.78)mg,明显低于对照组的(150.33±13.75)mm Hg、(90.32±4.36)mm Hg、(2960.33±41.48)mg,差异有统计学意义(P<0.05)。研究组患者治疗后的不良分娩结局发生率23.3%(7/30)明显低于对照组的70.0%(21/30),差异有统计学意义(P<0.05)。结论拉贝洛尔治疗重度子痫前期患者的临床疗效确切,能够帮助控制患者血压及24 h尿蛋白水平,改善患者不良分娩结局,应该给予大力的推广与应用。

Objective To analyze the effect of labetalol on blood pressure,24-h urinary protein level and delivery outcome in patients with severe preeclampsia.Methods A total of 60 patients with severe preeclampsia were divided into control group and research group according to the order of admission,with 30 cases in each group.Both groups were given conventional treatment.On this basis,patients in the control group were treated with nifedipine,and patients in the research group were treated with labelolol.The blood pressure,24-h urinary protein levels and adverse delivery outcomes were compared between the two groups.Results The systolic blood pressure,diastolic blood pressure and 24-h urinary protein levels were(139.27±13.68)mm Hg(1 mm Hg=0.133 kPa),(84.02±6.94)mm Hg and(2670.66±42.78)mg in the research group,which were significantly lower than those of(150.33±13.75)mm Hg,(90.32±4.36)mm Hg and(2960.33±41.48)mg in the control group,and the differences were statistically significant(P<0.05).After treatment,the incidence of adverse delivery outcomes of 23.3%(7/30)in the research group was lower than that of 70.0%(21/30)in the control group,and the difference was statistically significant(P<0.05).Conclusion Labelolol has definite clinical efficacy in the treatment of patients with severe preeclampsia,which can help control patients'blood pressure and 24-h urinary protein level,and improve patients'adverse delivery outcomes,so it should be vigorously promoted and applied.