自体外周血有核细胞注射改善眶周皱纹的效果

Efficacy of autologous peripheral blood nucleated cell therapy on periocular wrinkles

目的探讨真皮、皮下注射自体外周血有核细胞改善眶周皱纹的临床效果。方法 2019年6月至2021年6月, 四川大学华西口腔医院医疗美容科收治要求改善眶周皮肤细纹的女性患者18例, 年龄22~53(39.6±7.9)岁。抽取血液进行负收集混合法, 分离纯化出自体有核细胞和血液活性成分, 并均匀注射至患者眶周皮肤。单次治疗后用VISIA图像分析系统对治疗前后的眶周皱纹进行满意度评分, 将所得分值进行对比分析, 并记录治疗后并发症发生情况。结果术后1个月随访, 治疗前患者VISIA眶周静态皱纹(22.09±8.21)分, 治疗1个月后分值降至(18.31±7.84)分, 治疗前后评分差异(-3.77±2.14)分, 差异有统计学意义(t=7.50, P<0.05), 患者满意17例;随访3个月后满意15例。8例患者眶周皮肤纹理、质地、毛孔状态均得到改善。结论自体外周血有核细胞注射可改善眶周皮肤细纹、患者满意度高、几乎无不良反应, 值得临床应用。

Objective To explore the clinical effect of dermal and subcutaneous injection of au-tologous peripheral blood nucleated cells in improving periocular wrinkles.Methods Eighteen cases of beauty seekers who planned to improve periocular wrinkles were selected as the research objects of this study.Autologous nucleated cells and blood active components were isolated and purified by nega-tive collection mixed method and evenly injected into the periocular skin of patients.VISIA image a-nalysis system,and satisfactory score were used to detect and evaluate the related characteristics of periocular skin at different stages before and after treatment.The scores were compared and analyzed,and the complications after treatment were recorded.Results The 18 patients were followed up.The score of VISIA periorbital static wrinkles decreased from(22.09±8.21)before treatment to(18.31±7.84)one month after treatment,and the difference was statistically significant(t=-7.495,P<0.05).17 patients were satisfied;After 3 months of follow-up,15 cases were satisfied.The texture,consistency and pore state of periorbital skin were improved in some patients(10 cases).Conclusions Autologous peripheral blood nucleated cell therapy can improve periorbital wrinkles,es-pecially skin fine lines,and geta high satisfactory rate.There are almost no adverse reactions after the treatment,which is worthy of clinical application.