中西医结合外治法治疗黄褐斑的疗效

Efficacy of external treatment of integrated traditional Chinese and Western medicine on chloasma

目的探讨中西医结合外治法治疗色素合并血管型黄褐斑的效果。方法 2020年1月至2021年12月, 中国中医科学院西苑医院皮肤科选取色素合并血管型女性黄褐斑患者82例, 年龄26~50(44.5±14.0)岁。分为中医治疗组28例, 用中药倒膜结合面针围刺治疗;西医治疗组26例, 用湿敷0.5%氨甲环酸溶液治疗;中西医结合组28例, 用两种方案联合治疗, 8周后进行黄褐斑面积及严重程度评分(MASI), 用偏振光皮肤镜观察皮损区血管增生情况。结果 3组治疗后MASI评分均有下降, 中西医结合组MASI评分下降值为(8.60±4.53)分, 优于中医治疗组(6.26±3.20)分及西医治疗组(4.39±2.11)分(均P<0.05);3组治疗后血管增生下降值中西医结合组为(2.57±0.63)分, 西医治疗组为(1.55±0.51)分, 均大于中医治疗组(0.96±0.51)分(均P<0.05);而中西医结合组及西医治疗组血管增生下降值比较, 差异无统计学意义(P>0.05)。结论中西医结合外治法对色素合并血管型黄褐斑疗效显著, 氨甲环酸溶液湿敷可抑制黄褐斑患者的血管增生。

Objective To explore the efficacy of external treatment of integrated traditional Chi-nese and Western medicine on melanized type complicated with vascularized type of chloasma.Methods A total of 82 patients(aged 26-50 years,with an average age of 44.5 years)with melanized type complicated with vascularized type of chloasma were selected,and randomly divided into groups:28 cases in the traditional Chinese medicine control group were treated with traditional Chinese medi-cine pourmask combined with surrounded facial acupuncture;26 cases in Western medicine control group underwent wet compress with 0.5%tranexamic acid solution.In the integrated Chinese tradi-tional and Western medicine treatment group,28 cases were treated with 2 regimens.After 8 weeks,MASI score was carried out,and vascular hyperplasia in skin lesions was observed by polari-light skin scope.Results After treatment,the MASI scores in the three groups were all decreased,and the de-creasing rate of MASI scores from high to low was as follows:Integrated Chinese traditional and Western medicine treatment group(8.60±4.53)>TCM control group(6.26±3.20)>Western medicine control group(4.39±2.11).After treatment,the vascular hyperplasia scores in the three groups were all decreased,and the value of vascular hyperplasia in the integrated Chinese traditional and Western medicine treatment group(2.57±0.63)and Western medicine control group(1.55±0.51)was greater than that in TCM control group(0.96±0.51),but there was no significant differ-ence between the integrated Chinese traditional and Western medicine treatment group and Western medicine control group.Conclusions External treatment of integrated traditional Chinese and West-ern medicine is effective in the treatment of melanized type complicated with vascularized type of chloasma,and wet compress with tranexamic acid solution can inhibit vascular hyperplasia in patients with chloasma.