特发性中枢性性早熟女童的生活质量及影响因素调查

Investigation of quality of life and influencing factors in girls with idiopathic central precocious puberty

目的了解特发性中枢性性早熟女童的生活质量现状,分析其影响因素。方法研究设计为成组病例对照研究。病例组为2021年6月至2022年11月湖南省某三级甲等儿童医院确诊的135例特发性中枢性性早熟女童。对照组为同期长沙市内某两所小学就读的182例正常发育的女童。应用一般资料问卷、儿童生存质量普适性量表(PedsQL^(TM)4.0)进行调查。结果病例组儿童PedsQL^(TM)4.0总分、生理功能得分、情感功能得分、社交功能得分、学校表现得分均高于对照组,差异均有统计学意义(P<0.05)。多元回归分析显示,药物治疗疗程、家庭月收入、照顾者职业类型、医保、初复诊均是特发性中枢性性早熟女童的生活质量的影响因素。结论特发性中枢性性早熟女童的生活质量较低,医护人员应加强关注,提高其生活质量。

Objective To investigate the quality of life of girls with idiopathic central precocious puberty and analyze its influencing factors.Methods The study was designed as a cluster case-control study.The case group was made up of 135 girls with idiopathic central precocious puberty confirmed in a tertiary A children′s hospital in Hunan Province from June 2021 to November 2022.The control group was made up of 182 girls with normal development attending two primary schools in Changsha during the same period.The general information questionnaire,the Universal Child Quality of Life Scale(PedsQL^(TM)4.0)were used for investigation.Results The total scores of PedsQL^(TM)4.0,physiological function score,emotional function score,social function score,and school performance score of the children in the case group were higher than those in the control group,and the differences were statistically significant(P<0.05).Multiple regression analysis showed that the course of drug treatment,monthly household income,type of caregiver′s occupation,medical insurance,and initial follow-up were all influencing factors of the quality of life of girls with idiopathic central precocious puberty.Conclusion Girls with idiopathic central precocious puberty have a low quality of life,and medical staff should pay more attention in order to improve their quality of life.