割舌树中的两个新四降三萜walsurobustones F和G

Walsurobustones F and G:Two New Tetranortriterpenoids from Walsura robusta

四降三萜是众多芸香科及楝科中药材中的细胞毒活性成分,其化学结构上碳骨架多变、高度氧化。本文报道从割舌树叶片中分离得到了两个新的四降三萜类化合物,被命名为walsurobustones F(1)和G(2)。它们的结构通过一维与二维核磁,及质谱数据进行了解析。从结构上看,1和2是一对C-22位的差向异构体。细胞毒测试显示1和2对人肿瘤细胞株HL-60、SMMC-7721、A-549、MCF-7和SW480表现出了显著的细胞毒活性。

Tetranortriterpenoids are the major secondary metabolites in traditional Chinese medicine from family Meliaceae and Rutaceae,which structurally featured by diverse carbon skeletons and highly oxidized degree.Two new tetranortriterpenoids,walsurobustones F(1)and G(2),were isolated from the leaves of Walsura robusta.Their structures were elucidated by 1D NMR,2D NMR,and MS spectra.Structurally,1 and 2 are two geometric isomers that differ at position C-22.Both 1 and 2 showed obvious antitumor activity against the cancer cell lines HL-60,SMMC-7721,A-549,MCF-7,and SW480.These findings suggest that walsurobustones F(1)and G(2)have the potential to be used as anti-cancer agents.