骨关节炎病理变化过程的研究进展

The Latest Study of Pathological Changes of Osteoarthritis

骨关节炎(osteoarthritis,OA)是全世界老年人中常见的导致残疾和疼痛的慢性疾病,其特点是关节软骨的退行性改变、软骨下骨硬化、骨赘的形成、骨软骨血管生成和关节炎症,最终发生关节软骨退变、断裂、缺损,甚至整个关节面的损害。目前OA的发病机制尚未阐明,有效的治疗药物仍缺乏。本文就骨关节炎早期到晚期病理变化的动态过程进行综述。

Osteoarthritis(OA)is a common chronic disease causing disability and pain in older adults worldwide.It is characterized by degeneration of articular cartilage,subchondral osteosclerosis,osteophyte formation,cartilage angioge-nesis,and inflammation of the joint.Unfortunately,a series of damages will be caused,such as degeneration of articular cartilage,fracture,defect,and the entire articular surface injury.As the pathogenesis of OA has not been clarified,effective drugs for the patients are almost blank.This article reviews the pathological changes from early stage to late stage of osteoarthritis according to the existing reports.