摘要
Heterotopic ossification(HO)describes bone formation at non-skeletal sites and results from traumatic injury,surgery,or genetic disease such as fibrodysplasia ossificans progressiva(FOP).1,2 Although it is known that BMP signaling regulates HO,knowledge about the developmental origin of the osteogenic progenitors responsible for the BMP-associated metamorphosis is comparably less.With the use of transgenic mice and labelled neural crest-derived cell,3 we found myelin protein zero(P0,or MPZ)-and Wnt1-lineage cells give rise to BMP-7 induced adult ectopic cartilage and bone.
基金
supported by grants-in-aid for scientific research from the Japan Society for the Promotion of Science(JSPS)(No.16K15662)
iPS Cell Research Fund(No.200154400002)
Suzuken Memorial Foundation(No.21-008),the Core Center for iPS Cell Research of the Research Center Network for Realization of Regenerative Medicine(No.21bm0104001h0009)
the Practical Research Project for Rare/Intractable Diseases(No.16ek0109161h0002)from the Japan Agency for Medical Research and Development(AMED)to MI
This work was also supported by grants-in-aid for scientific research from JSPS(No.19K16540 and 21K06855)to CZ.
