癌相关成纤维细胞在肿瘤放疗抵抗中的研究进展

Research progress of cancer-associated fibroblasts in tumor radiotherapy resistance

癌相关成纤维细胞(CAF)是肿瘤放疗效果严重受限的关键因素。CAF作为肿瘤微环境中的主要基质细胞,可通过分泌促肿瘤细胞因子和营养物质、抑制抗肿瘤免疫反应和重塑细胞外基质等导致肿瘤放疗抵抗。靶向CAF增敏放疗的研究已取得一定进展,但相关研究体系仍不完善。因此,系统探讨CAF在肿瘤放疗抵抗中的作用及其靶向治疗策略,可为改善肿瘤放疗抵抗现状提供依据。

Cancer-associated fibroblasts(CAFs)is considered as a key factor for the severely limited efficacy in tumor radiotherapy.CAFs,as the primary stromal cells in the tumor microenvironment,can lead to tumor radiotherapy resistance by secreting a series of pro-tumor cytokines and nutrients,inhibiting anti-tumor immune response and remodeling extracellular matrix.Some progress has been made in the study of targeted CAFs sensitization radiotherapy,but the relevant study system is still imperfect.Therefore,a systematic exploration of the role of CAFs in tumor radiotherapy resistance and CAFs targeted therapy strategies can provide a basis for improving the current status of tumor radiotherapy resistance.