铜绿假单胞菌动物感染模型的构建及研究进展

Constructions and advances of animal models of Pseudomonas aeruginosa infection

铜绿假单胞菌是一种致病机制和耐药机制复杂、发病率和死亡率高的机会致病菌,可致免疫功能低下个体各种组织部位的急、慢性感染,临床以肺部感染、伤口感染和血流感染最为常见。铜绿假单胞菌动物感染模型通过模拟人体细菌感染途径,对深入研究铜绿假单胞菌致病性、耐药性及其防治措施具有重要的应用价值。本文就铜绿假单胞菌动物感染模型构建中实验动物的选择、麻醉和处置进行概述,并对铜绿假单胞菌肺部感染、伤口感染和血流感染动物模型的构建方法、模型评估以及应用进行阐述,以期为铜绿假单胞菌感染性疾病相关科学研究工作提供参考。

Pseudomonas aeruginosa(P.aeruginosa)is an opportunistic pathogenic bacterium with complex pathogenesis and drug resistance mechanisms.It has high morbidity and mortality and can cause acute and chronic infections in immunocompromised individuals,with lung infections,wound infections,and bloodstream infections being the most common.The animal infection model of P.aeruginosa is of great value for in-depth research on the pathogenicity,drug resistance,and therapeutic measures of P.aeruginosa by simulating the pathways of human bacterial infections.This article firstly summarizes the selection,anesthesia,and disposal of experimental animals in the construction of animal models of P.aeruginosa infection,and then reviews the methods of construction,model evaluation,and applications of animal models of P.aeruginosa pulmonary infection,wound infection,and bloodstream infection,in order to provide a reference for scientific research related to P.aeruginosa infectious diseases.