幽门螺杆菌硫氧还蛋白的研究进展

Progress in Research on Helicobacter pylori Thioredoxin

幽门螺杆菌(Hp)感染是胃癌发生的主要原因之一。在欧美国家,Hp毒力因子细胞毒素相关基因A(CagA)和空泡毒素A(VacA)与Hp的致病性密切相关。然而在东亚国家,CagA的阳性率高达90%,并不能完全解释Hp致病性的差异,可能存在其他致病因子。本课题组的前期研究发现硫氧还蛋白1(Trx1)可能为高致病性Hp的毒力因子,并针对Hp Trx1在细胞学、动物学、人体组织学等方面进行了一系列研究。本文就Hp Trx1的研究进展作一综述。

Helicobacter pylori(Hp)infection is one of the main causes of gastric cancer.The virulence factors of Hp,cytotoxin⁃associated gene A(CagA)and vacuolating cytotoxin A(VacA),are closely related to the pathogenicity of Hp in European and American countries.However,the positivity rate of CagA is as high as 90%in East Asian countries,indicating that the above⁃mentioned virulence factors could not fully explain the differences in pathogenicity of Hp,and other pathogenic factors might be speculated.In our previous studies,thioredoxin⁃1(Trx1)was found to be a virulence factor of highly pathogenic Hp,and a series of studies were conducted on Hp Trx1 in cytology,zoology and human histology.This article reviewed the progress in research on Hp Trx1.