中医经典名方槐花散的现代研究进展

Research progress of the classical TCM formula Huaihua powder

槐花散出自南宋许叔微所著《普济本事方》,乃治“肠风脏毒”(肠风下血)的经典方。现代研究表明,槐花散主要含有黄酮类、挥发油、皂苷类等活性成分,具有抗炎、抗氧化、止血等多种药理作用。临床大多用于溃疡性结肠炎、放射性肠炎、痔疮术后出血以及出血性肛肠疾病、过敏性紫癜等皮肤病的治疗,其现代临床应用较古代临床应用稍有发挥。本文从化学成分及分析方法、工艺研究与质量控制、现代药理及临床应用四个方面进行总结与归纳,探讨其药效物质基础及研究方向。基于研究结果,结合槐花散的现代药理及临床应用,建议开发该经方的整方药理活性成分以及治疗放射性肠炎、过敏性紫癜及其他皮肤病的主要有效成分、抗炎靶点及作用机制。

Huaihua powder,a classical TCM formula,was initially recorded in Pu Ji Ben Shi Fang by the prestigious physician Xu Shuwei.It is a classical prescription for treating"chang-feng-zang-du"(chang-feng-xia-xue).Modern research shows that the main components of Huaihua powder are flavonoids,volatile oil,saponins and so on,which have anti-inflammatory,antioxidant,hemostatic,antibacterial,anti-tumor and other pharmacological effects.The clinical application is mostly used for the treatment of ulcerative colitis,radioactive enteritis,hemorrhoid postoperative bleeding and other skin diseases.Its modern clinical application is slightly better than the ancient clinical application.This paper summarized and summarized the chemical composition and analysis method,process research and quality control,modern pharmacology and clinical application,and discussed the material basis and research direction of its efficacy.Based on the research results,combined with the modern pharmacology and clinical application of Huaihua powder,it is recommended to develop the entire pharmacological active ingredients of this classic formula,as well as the main effective ingredients,anti-inflammatory targets,and mechanism of action for the treatment of radiation induced enteritis,allergic purpura,and other skin diseases.