心理应激与冠状动脉微血管疾病的相关性研究进展

Correlation Between Psychological Stress and Coronary Microvascular Disease

许多心绞痛患者在接受冠状动脉造影时没有发现明显的阻塞性冠状动脉病变,其中超过50%的患者诊断为冠状动脉微血管疾病。冠状动脉微血管疾病严重影响了患者的生活质量,增加了主要不良心血管事件的发生风险,但其病因及发病机制尚不完全明确。心理应激是人体通过认识、评价而感受到应激原的刺激时引起的心理、生理机能改变的过程。近年来随着双心医学的提出以及生物-心理-社会医学模式的逐渐发展,心理应激与冠状动脉微血管疾病的发生、发展及预后的关系受到人们的高度关注。现总结既往研究,对心理应激与冠状动脉微血管疾病之间的相关性进行综述,旨在为冠状动脉微血管疾病的诊治提供帮助。

Many angina patients undergo coronary angiography without significant obstructive coronary artery disease,and more than 50%of these patients are diagnosed with coronary microvascular disease.Coronary microvascular disease seriously affects the quality of life of patients and increases the risk of major adverse cardiovascular events.However,the etiology and mechanism of coronary microvascular disease are still unclear.Psychological stress is a process in which the body changes its psychological and physiological functions when it feels the stimulation of stressors through recognition and evaluation.In recent years,the relationship between psychological stress and the occurrence,development,prognosis of coronary microvascular diseases has attracted extensive attention with the proposal of psycho-cardiology and the gradual development of bio-psycho-social medical model.This article summarizes the previous studies and reviews the correlation between psychological stress and coronary microvascular disease,aiming to provide help for the diagnosis and treatment of coronary microvascular disease.