摘要
An NHC-catalyzed regiospecific allylation ofα-substituted allenoates with MBH carbonates derived from aryl aldehyde furnished highly functionalized 1,5-enynes bearing a quaternary carbon successfully.Combining with DFT calculations,the reaction mechanism of this conversion was proposed.This method has the advantages of high regioselectivity,good yields and mild reaction conditions.This transformation not only provided a new access to 1,5-enyne,but also enriched the chemistry of allenoates and NHC catalysis.
基金
support by National Natural Science Foundation of China(No.21871113,21773214,21372101)
a project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institution and TAPP.
