摘要
An efficient trifluoromethylation reaction of vinyldiazoacetates under mild reaction conditions was depicted.Pre-generated CuCF_(3) was used as a trifluoromethylation reagent and water acted as both a promoter and proton source.The reaction is compatible with a broad scope of functional groups and easy to scale-up.The wide functional group tolerance of the reaction enables further synthetic manipulation of the products.
基金
the National Natural Science Foundation of China(21901196)
the Natural Science Basic Research Plan in Shaanxi Province of China(2020JQ-016)
Xi’an Jiaotong University(71211920000001)for financial support.
