摘要
The pharmaceutically significant 2,3-dihydroquinolin-4-one scaffolds were constructed diastereoselectively and facilely via redox-neutral cascade Knoevengel condensation/[1,7]-hydride transfer/cyclization/transesterification in DCE from readily available methyl 2-aminobenzoacetate and diverse aldehydes,which features novel and highly valuable product structures.
基金
We are grateful to the NSFC(21978144,21702117,and 21776148)
the Key Research&Development Program of Shandong Province(2018GSF118224,2019GSF108020,and 2019RKB01027)
the Support Plan on Science and Technology for Youth Innovation of Universities in Shandong Province(2019KJM002)
The financial support from the Talents of High Level Scientific Research Foundation(6631110309 and 630916)
the assistance from Dr Fengying Dong(Central Laboratory of Qingdao Agricultural University)for NMR determination are also gratefully acknowledged.
