摘要
Herein we report the deoxygenated fluorination of readily available carboxylic acids.A series of acyl fluorides have been synthesized using shelf-stable N-trifluoromethylthiophthalimide as a fluorinated reagent for the first time.Scale-up reactions and sequential cross-couplings were performed successfully to demonstrate the practicability of this fluorination protocol.
基金
financially supported by the King Abdullah University of Science and Technology(KAUST),Saudi Arabia,Office of Sponsored Research(URF/1/4384).
