摘要
Due to their unique activation modes,small organic molecule catalysts(organocatalysts)have proved their potential in facilitating the remote functionalizations of unsaturated acceptors with extended conjugation.The organocatalytic 1,6-addition reaction involving the attack of nucleophiles on the δ-carbon of the α,β,γ,δ-unsaturated acceptors has emerged as an excellent strategy to create a stereocenter at the δ-site with high regio-and stereo-control.Organocatalysis has also opened the window for developing complex domino reactions involving the 1,6-addition step.Tremendous advancement has been accomplished in the organocatalytic asymmetric 1,6-addition and related domino reactions for the stereocontrolled synthesis of complex molecular structures bearing multiple stereocenters.This review article summarizes the significant advancement in stereoselective domino reactions involving 1,6-addition as a critical step.
基金
financial support from the Council of Scientific and Industrial Research(CSIR),India(File No.:02(0422)/21/EMR-Ⅱ)
the Indian Institute of Technology Jammu for providing Seed Grant(File No.:SG0002)to establish the independent research group
the Indian Institute of Technology Jammu for the fellowships.
