中药单体治疗AD线粒体自噬的研究进展

Research Progress of Chinese Medicine Monomer in Treatment of Mitophagy in AD

阿尔茨海默病(AD)是一种以思维和个人日常活动的独立性逐渐下降为主要特征的神经退行性疾病,它也是痴呆的主要类型。最新的研究发现,线粒体自噬与AD的发病密切相关,同时多种中药有效成分对线粒体自噬参与的AD发生、发展过程有较好的治疗作用。本文总结了PINK1-Parkin通路、ROS和NAD+介导的线粒体自噬在AD发病过程中所体现的关键性作用,并详尽阐述了小檗碱、穿心莲内酯、β-细辛醚等多种中药单体从多靶点、多角度保护线粒体自噬功能受损防治AD的研究进展。

Alzheimer s disease(AD)is a neurodegenerative disease characterized by a gradual decline in the independence of thinking and daily activities.It is also the main type of dementia.The latest studies have found that mitophagy is closely related to the pathogenesis of AD,and a variety of effective ingredients of Chinese medicinal have good therapeutic effects on occurrence and development of AD involved in mitophagy.This study summarized the key roles of PINK1-Parkin pathway,ROS and NAD+mediated mitophagy in the pathogenesis of AD.In addition,the research progress of berberine,andrographolide,β-asarone and other Chinese medicinal monomers in prevention and treatment of AD through multi-target and multi-way protection of mitophagy was described in details.