美沙拉嗪联合复方谷氨酰胺治疗活动期轻中度溃疡性结肠炎的效果探讨

Discussion on effect of mesalazine combined with compound glutamine in the treatment of active mild to moderate ulcerative colitis

目的 分析美沙拉嗪联合复方谷氨酰胺治疗活动期轻中度溃疡性结肠炎的效果。方法 60例活动期轻中度溃疡性结肠炎患者,采用随机数字表法分为对照组和联合治疗组,每组30例。对照组患者给予美沙拉嗪治疗,联合治疗组患者在对照组基础上联合复方谷氨酰胺治疗。比较两组脓血黏液便完全消失时间、腹痛不适缓解时间、腹泻消失时间,治疗前后肿瘤坏死因子-α、白细胞介素-6、热休克蛋白70(HSP70)水平及疾病活动性指数,治疗效果,不良反应发生情况。结果 联合治疗组脓血黏液便完全消失时间、腹痛不适缓解时间、腹泻消失时间分别为(4.01±0.24)、(3.01±1.51)、(3.26±1.26)d,短于对照组的(6.54±1.42)、(5.25±1.18)、(4.67±1.12)d,差异具有统计学意义(P<0.05)。治疗后,两组肿瘤坏死因子-α、白细胞介素-6水平及疾病活动性指数均低于本组治疗前,HSP70水平高于本组治疗前,且联合治疗组肿瘤坏死因子-α(1.51±0.21)ng/ml、白细胞介素-6(45.01±10.45)ng/L、疾病活动性指数(2.11±0.15)分显著低于对照组的(2.42±0.28)ng/ml、(68.01±15.65)ng/L、(3.68±0.57)分,HSP70(446.57±80.11)μg/L显著高于对照组的(326.68±56.13)μg/L,差异具有统计学意义(P<0.05)。联合治疗组总有效率为96.67%,高于对照组的70.00%,差异具有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论 美沙拉嗪联合复方谷氨酰胺对于活动期轻中度溃疡性结肠炎的治疗效果确切,有利于加速腹痛和腹泻等症状的好转,降低炎症反应,安全性高。

Objective To analyze the effect of mesalazine combined with compound glutamine in the treatment of active mild to moderate ulcerative colitis.Methods A total of 60 patients with active mild to moderate ulcerative colitis were divided into control group and combined treatment group according to the random numerical table,with 30 cases in each group.The control group was treated with mesalazine,and the combined treatment group was treated with compound glutamine on the basis of the control group.Both groups were compared in terms of the time of complete disappearance of purulent mucus stools,the time of relief of abdominal pain and discomfort,the time of disappearance of diarrhea,the levels of tumor necrosis factor-α,interleukin-6 and heat shock protein 70(HSP70)before and after treatment,the disease activity index,the therapeutic effect,and the occurrence of adverse reactions.Results The time of complete disappearance of purulent mucus stools,the time of relief of abdominal pain and discomfort,the time of disappearance of diarrhea were(4.01±0.24),(3.01±1.51)and(3.26±1.26)d in the combined treatment group,which were shorter than those of(6.54±1.42),(5.25±1.18)and(4.67±1.12)d in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of tumor necrosis factor-α,interleukin-6 and disease activity index in the two groups were lower than those before treatment in this group,while the level of HSP70 was higher than that before treatment in this group;combined treatment group had tumor necrosis factor-αof(1.51±0.21)ng/ml,interleukin-6 of(45.01±10.45)ng/L and disease activity index of(2.11±0.15)points,which were significantly lower than those of(2.42±0.28)ng/ml,(68.01±15.65)ng/L and(3.68±0.57)points in the control group;HSP70 of(446.57±80.11)μg/L in the combined treatment group was significantly higher than that of(326.68±56.13)μg/L in the control group;the differences were statistically significant(P<0.05).The total effective rate of 96.67%in the combined treatment group was higher than that of 70.00%in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Mesalazine combined with compound glutamine is effective in the treatment of active mild to moderate ulcerative colitis,which is conducive to accelerating the improvement of abdominal pain and diarrhea,reducing the inflammation,and has high safety.