具核梭杆菌与口腔鳞状细胞癌关系的研究进展

Research progress of the relationship between Fusobacterium nucleatum and oral squamous cell carcinoma

具核梭杆菌(Fusobacterium nucleatum,Fn)作为人类口腔微生态的常驻菌群,已被证实为牙周炎的主要致病菌,参与牙周病的发生发展。近年来,大量证据表明,Fn负载的增加与口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)的发展和预后关系密切。Fn可能通过增强肿瘤细胞增殖、侵袭迁移能力及耐药性等多种肿瘤生物学特性,促进OSCC的发生发展。此外,以Fn为靶标的靶向治疗策略为OSCC的防治提供了新思路。本文综述了Fn促进OSCC发生发展相关的潜在机制,并对OSCC的Fn靶向治疗进行总结与展望,以期为OSCC的防治提供新的理论基础。

Fusobacterium nucleatum(Fn),as the resident flora of human oral microecology,has been proved to be the main pathogen of periodontitis,participating in the occurrence and development of periodontal disease.In recent years,a large amount of evidence shows that the increase of Fn load is closely related to the development and prognosis of oral squamous cell carcinoma(OSCC).Fn may promote the occurrence and development of OSCC by enhancing tumor cell proliferation,invasion and migration ability and drug resist⁃ance.In addition,the targeted therapy targeting at Fn provides a new idea for the prevention and treatment of OSCC.In this paper,the potential mechanism of Fn promoting the occurrence and development of OSCC is reviewed,and the Fn targeted therapy of OSCC is summarized and prospected,so as to provide a new theoretical basis for the prevention and treatment of OSCC.