牙周炎氧化应激水平与铁代谢的研究进展

Research progress of oxidative stress level and iron metabolism in periodontitis

牙周炎被认为是牙周致病菌导致的牙周破坏性疾病,通过破坏牙周组织,最终导致牙齿丧失。铁作为人体中重要的微量元素之一,参与机体的各项生理活动。铁代谢平衡是维持正常生理功能的重要组成部分,其代谢异常与多种疾病相关。铁稳态失调会促使活性氧(reactive oxygen species,ROS)水平增高,破坏氧化与抗氧化防御系统之间的平衡,从而导致氧化应激,进一步破坏牙周组织,增加牙周炎的发病率。多项研究表明,铁代谢异常与牙周炎的发生发展存在一定关系,影响牙周炎的病程进展及预后情况。该文将就牙周炎中ROS导致氧化应激与铁代谢机制的研究进展展开综述,从铁代谢方向为牙周炎防治提供新思路。

Periodontitis is considered to be a destructive periodontal disease caused by periodontal pathogens,which eventually leads to tooth loss through the destruction of periodontal tissue.As one of the important trace elements in human body,iron participates in va⁃rious physiological activities of the body.Iron metabolism balance is an important part in maintaining the physiological function and its metabolic abnormality is associated with various diseases.Dysregulation of iron homeostasis can promote the increase of reactive oxygen species(ROS)level and destroy the balance between oxidative and antioxidant defense systems,thus leading to oxidative stress,further damaging the periodontal tissue and increasing the incidence of periodontitis.Several studies have shown that there is a certain relation⁃ship between abnormal iron metabolism and the occurrence and development of periodontitis,which affects the course and prognosis of periodontitis.This article reviews the research progress of ROS⁃induced oxidative stress and the mechanism of iron metabolism in peri⁃odontitis,and provides new ideas for the prevention and treatment of periodontitis from the direction of iron metabolism.