围绝经期综合征女性性激素水平与负性情绪的关系研究

Relationship between sex hormone level and negative emotions in women with perimenopausal syndrome

目的 探究围绝经期综合征女性性激素水平与负性情绪的关系。方法 选取遂宁市中心医院2018年7月—2022年3月收治的104例围绝经期综合征女性作为研究对象,采用全自动生化分析仪检测睾酮(testosterone,T)、促黄体生成素(luteinizing hormone,LH)、孕酮(progesterone,P)、促卵泡生成素(follicle stimulating hormone,FSH)、雌二醇(estradiol,E2)等雌激素水平,并采用汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)及汉密尔顿焦虑量表(Hamilton Anxiety Scale,HAMA)评估负性情绪。评估受试者性激素表达水平及情绪评分、不同情绪评分水平患者的性激素表达水平、性激素水平与负性情绪的相关性。结果 104例围绝经期综合征患者HAMD评分中正常21例(20.19%)、轻度抑郁24例(23.08%)、中度抑郁44例(42.31%)、重度抑郁15例(14.42%);HAMA评分中正常20例(19.23%)、轻度焦虑22例(21.15%)、中度焦虑46例(44.23%)、重度焦虑16例(15.38%)。不同抑郁、焦虑程度组的血清T、P水平比较差异均有统计学意义(P<0.05);重度抑郁组血清T水平高于正常组,P水平低于正常组(P<0.05);重度焦虑组血清T水平高于正常组,P、E2水平低于正常组(P<0.05)。Pearson分析显示,T水平与HAMD、HAMA评分均呈正相关(P<0.05);P水平与HAMD、HAMA评分均呈负相关(P<0.05)。结论 围绝经期综合征患者的T水平与HAMD、HAMA评分均呈正相关,P水平与HAMD、HAMA评分均呈负相关。

Objective To explore the relationship of sex hormone level with negative emotions in women with perimenopausal syndrome.Methods One hundred and four women with perimenopausal syndrome hospitalized in Suining Central Hospital from July 2018 to March 2022 were selected as the research subjects.Automatic biochemical analyzer was used to detect the levels of testosterone(T),luteinizing hormone(LH),progesterone(P),follicular stimulating hormone(FSH),estradiol(E2)and other estrogens.Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA)were employed to evaluate negative emotions.We evaluated the subjects' expression levels of sex hormones and emotional scores,the expression levels of sex hormones in patients with different emotional scores,and the correlation between sex hormone levels and negative emotions.Results As for the 104 perimenopausal syndrome patients' HAMD scores,there were 21(20.19%)patients with normal score,24(23.08%)with mild depression,44(42.31%)with moderate depression,and 15(14.42%)with severe depression.As for the 104 perimenopausal syndrome patients' HAMA scores,there were 20(19.23%)patients with normal score,22(21.15%)with mild anxiety,46(44.23%)with moderate anxiety,and 16(15.38%)with severe anxiety.Serum levels of T and P showed statistically significant differences among groups with different levels of depression and anxiety(P<0.05).Serum level of T was higher in the severe depression group than in the normal group,while serum level of P was lower in the severe depression group than in the normal group(P<0.05).Serum level of T was higher in the severe anxiety group than in the normal group,whereas serum levels of P and E2 were lower in the severe anxiety group than the normal group(P<0.05).Pearson analysis revealed that serum T level was positively correlated with HAMD and HAMA scores(P<0.05),while serum P level was negatively correlated with HAMD and HAMA scores(P<0.05).Conclusion Serum T level of the patients with perimenopausal syndrome is positively related to HAMD and HAMA scores,but serum P level is inversely associated with HAMD and HAMA scores.