动态脑电图在帕金森病患者认知功能中的评估价值及其参数与患者血清维生素D、MIF水平的相关性

Evaluation value of ambulate electroencephalogram in cognitive function of patients with Parkinson's disease and the correlation of its parameters with the levels of serum vitamin D and MIF of patients

目的:探究动态脑电图(AEEG)在帕金森病(PD)患者认知功能评估中的应用价值及其参数与患者血清25-羟维生素D[25-(OH)D]、巨噬细胞游走抑制因子(MIF)水平的相关性。方法:选取106例PD患者纳入观察组,采用蒙特利尔认知评估量表(MoCA)评估其认知功能。其中认知功能正常的36例患者纳入A组;轻度认知功能障碍的39例患者纳入B组;PD痴呆的31例患者纳入C组;选择同期45名健康体检者纳入对照组。所有研究对象均行AEEG检查。比较各组研究对象脑电图(EEG)参数及血清25-(OH)D、MIF水平。采用Pearson法分析EEG参数与血清25-(OH)D、MIF水平的相关性,并采用受试者工作特征曲线(ROC)分析EEG各参数单独及联合评估PD患者认知功能的价值。结果:观察组与对照组及A、B、C 3组间的α1波、α2波、β1波、β2波脑电功率比较,差异均无统计学意义(P>0.05)。观察组θ波、δ波脑电功率及MIF水平均高于对照组(P<0.05),25-(OH)D水平低于对照组(P<0.05)。A、B、C组θ波、δ波脑电功率及MIF水平依次升高,25-(OH)D水平依次降低。相关性分析结果显示,θ波、δ波脑电功率与25-(OH)D负相关(r=-0.716、-0.650,P<0.05),与MIF正相关(r=0.746、0.723,P<0.05)。ROC曲线分析结果显示,θ波、δ波脑电功率单独及联合检测对PD患者认知功能评估的ROC曲线下面积(AUC)分别为0.896、0.901、0.962。结论:PD患者EEG发生异常,血清25-(OH)D表达水平降低及MIF表达水平升高,EEG参数中的θ波、δ波和上述血清指标之间及与患者认知功能均有密切联系,且θ波、δ波联合评估PD患者认知功能具有较高的应用价值。

Objective:To explore the application value of ambulate electroencephalogram(AEEG)in the assessment of cognitive function in patients with Parkinson's disease(PD)and the correlation of parameters with the levels of serum 25-hydroxyvitamin D[25-(OH)D]and migration inhibitory factor(MIF)of patients.Methods:106 PD patients were included in the observation group,their cognitive function was assessed using the Montreal cognitive assessment scale(MoCA).36 patients with normal cognitive function were included in group A,39 patients with mild cognitive impairment were included in group B,and 31 patients with PD dementia were included in group C,45 healthy subjects during the same period were included in the control group.All subjects underwent AEEG examination.The electroencephalogram(EEG)parameters,the levels of serum 25-(OH)D and MIF were compared among all groups of study objects.Pearson method was used to analyze the correlation between EEG parameters and the levels of serum 25-(OH)D,MIF,and receiver operating characteristic curve(ROC)was used to analyze the value of EEG parameters individually and jointly in the assessment of cognitive function in PD patients.Results:There were no significant differences in the EEG power ofα1 wave,α2 wave,β1 wave andβ2 wave between the observation,control group and group A,B,and C(P>0.05).The EEG power ofθ,δwave and MIF level in observation group were higher compared with those in the control group(P<0.05),and the 25-(OH)D level was lower compared with the control group(P<0.05).The EEG power ofθ,δwave and MIF level in group A,B and C were successively increased,while the 25-(OH)D level was successively decreased.The correlation analysis results showed that the EEG power ofθwave andδwave were negatively correlated with 25-(OH)D(r=-0.716,-0.650,P<0.05),and those were positively correlated with MIF(r=0.746,0.723,P<0.05).ROC curve analysis results showed that the values of area under curve(AUC)of ROC curve of the EEG power ofθwave,δwave alone and jointly in the assessment of cognitive function of PD patients were 0.896,0.901 and 0.962,respectively.Conclusion:The EEG of PD patients is abnormal,the expression level of serum 25-(OH)D is decreased and MIF is increased,which theθ,δwave of EEG parameters,serum indexes are closely related to each other and the cognitive function of patients,and the combination ofθwave andδwave have a high application value in the assessment of cognitive function in PD patients.