氧糖剥夺条件下神经细胞损伤机制研究进展

Research Progress on the Mechanism of Nerve Cell Injury Under Oxygen Glucose Deprivation

氧糖剥夺(oxygen glucose deprivation,OGD)通过对细胞培养条件的改变,模拟细胞在缺血/缺氧情况下的损伤,是在细胞层面上模拟缺血/缺氧常用的一种刺激模型。神经系统的细胞主要由神经元和神经胶质细胞组成,缺血缺氧后细胞会产生坏死、凋亡、自噬等现象,中枢神经系统的OGD往往导致不可逆的、毁灭性的后果,最终导致神经功能受损。OGD诱导的神经细胞损伤机制非常复杂,主要有细胞凋亡、钙离子超载、氧化应激、兴奋性氨基酸增多、能量代谢障碍等,这些要素并不是独立的,而是相互影响、互为因果的。因此,该文拟对OGD条件下神经细胞损伤机制研究进展进行综述。

Oxygen glucose deprivation(OGD)based on the change of cell culture conditions,simulation cells in ischemia/hypoxia injury cases,at the cellular level is simulated ischemia/hypoxia stimulation models in common use.The cells of the nervous system mainly include neurons and glial cells.After ischemia and hypoxia,cells will produce necrosis,apoptosis,autophagy,other phenomena.OGD of the central nervous system often leads to irreversible and devastating consequences,and ultimately leads to neurological impairment.The mechanism of nerve cell injury under OGD condition is very complex,including apoptosis,calcium overload,oxidative stress,excitatory amino acid increase,energy metabolism disorder,etc.Each factors does not exist in isolation but influences and causes each other.Therefore,this paper intends to review the research progress of nerve cell injury mechanism under OGD condition.