摘要
胰岛素抵抗和胰岛β细胞功能障碍被认为是2型糖尿病(T2DM)发病的2个重要因素。近年来的研究表明,T2DM的发病机制与内质网应激(ERS)介导的细胞凋亡有关。胰岛β细胞内有高度发达的内质网,是对ERS最敏感的细胞之一。在ERS状态下,内质网会通过未折叠蛋白反应(UPR)来调节应激,但强烈刺激的应激使UPR反应失调,诱导胰岛β细胞凋亡,进而参与糖尿病的发生、发展。该文就ERS相关信号通路在T2DM发病机制中的作用进行了综述,以期为T2DM的中医治疗提供一定的科学依据。
Insulin resistance and pancreatic isletβ-cell dysfunction are considered to be two important factors in the pathogenesis of type 2 diabetes(T2DM).Recent studies have shown that the pathogenesis of T2DM is related to endoplasmic reticulum stress(ERS)-mediated apoptosis.Pancreatic isletβ-cell has a highly developed endoplasmic reticulum,which is one of the most sensitive cells to ERS.In ERS state,endoplasmic reticulum will regulate stress through unfolded protein response(UPR),but strong stimulation stress will cause UPR reaction disorder and induce pancreatic isletβ-cell apoptosis,and then participate in the occurrence and development of diabetes.The article reviews the role of ERS related signaling pathways in the pathogenesis of T2DM,in order to provide a certain scientific basis for the traditional Chinese medicine treatment of T2DM.
作者
关晓文(综述)
梁永林
朱向东
苏菲
张媛媛
崔泽方(审校)
GUAN Xiaowen;LIANG Yonglin;ZHU Xiangdong;SU Fei;ZHANG Yuanyuan;CUI Zefang(School of Basic Medicine,Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu 730000,China;Key Laboratory of Dunhuang Medicine and Transformation of Education Ministry,Lanzhou,Gansu 730000,China;College of Traditional Chinese Medicine,Ningxia Medical UniversityYinchuan,Ningxia 750004,China)
出处
《现代医药卫生》
2023年第13期2263-2266,共4页
Journal of Modern Medicine & Health
基金
甘肃省教育厅产业支撑计划项目(2021CYZC-03)
宁夏回族自治区重点研发计划项目(2022CMG02034)。
关键词
内质网
细胞凋亡
2型糖尿病
综述
Endoplasmic reticulum
Apoptosis
Type 2 diabetes
Review
