靶向抑制NLRP3炎性小体在脊髓损伤中的研究进展

Research progress of targeted inhibition of NLRP3 inflammasome in spinal cord injury

脊髓损伤(SCI)是一种难以治愈的神经创伤性疾病,常见病因包括高空坠落、交通事故和重物砸伤等。炎症反应是机体在遭遇外界刺激时产生的免疫保护防线,适当的炎症反应可保护机体免受内外源性侵害。核苷酸结合寡聚结构域样受体蛋白3(NLRP3)炎性小体作为目前研究最多的炎性小体,研究发现其在SCI后表达量显著增加,并介导炎症级联反应。该文就NLRP3的激活机制及脊髓损伤后靶向抑制NLRP3激活机制的相关措施进行综述。

Spinal cord injury(SCI)is a neurotraumatic disease that is difficult to cure,and common causes include falling from height,traffic accident and heavy object injury.Inflammatory response is an immune protection produced by body in response to external stimuli.Appropriate inflammatory response can protect body from endogenous and external damage.The nucleotide-binding domain-like receptor protein 3(NLRP3)inflammasome,as the most studied inflamolosome,has significantly increased expression after SCI and mediates the inflammatory cascade.This article reviews the activation mechanism of NLRP3 and relevant measures to inhibit the activation mechanism of NLRP3 after SCI.