无创呼吸机联合沙丁胺醇治疗慢性阻塞性肺疾病并发呼吸衰竭的效果及对炎症因子的影响

Effect of Noninvasive Ventilator Combined with Salbutamol on Chronic Obstructive Pulmonary Disease Complicated with Respiratory Failure and Its Effect on Inflammatory Factors

目的探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)并发呼吸衰竭(respiratory failure,RF)患者使用无创呼吸机与沙丁胺醇联合治疗的效果,以及对于炎性因子的影响。方法选取2021年10月—2022年9月菏泽市牡丹人民医院收治的COPD并发RF患者89例为研究对象,以随机数表法分为两组,即对照组(44例)与研究组(45例)。对照组采用无创呼吸机通气治疗,研究组在此基础上联合沙丁胺醇治疗。比较两组呼吸功能指标、血清炎症因子,以及不良反应情况。结果治疗1周后,研究组血二氧化碳分压(PaCO_(2))(40.60±3.28)mmHg低于对照组(46.50±4.03)mmHg,动脉血氧分压(PaO_(2))指标(96.66±4.87)mmHg、PaO_(2)/吸入氧浓度(FiO_(2))指标(367.72±9.55)mmHg高于对照组(89.80±5.95)、(355.22±8.85)mmHg,差异有统计学意义(t=7.583、5.958,6.401,P<0.05)。治疗1周后,研究组C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)指标均低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论COPD并发RF患者应用无创呼吸机联合沙丁胺醇治疗效果确切,可以有效改善呼吸功能,抑制炎性因子。

Objective To investigate the effect of chronic obstructive pulmonary disease(COPD)combined with salbutamol in patients with respiratory failure(RF),and the effect on inflammatory factors.Methods A total of 89 patients with COPD complicated with RF treated in Peony People′s Hospital of Heze City from October 2021 to September 2022 were selected as research objects,and divided into two groups by random number table method,namely control group(44 cases)and study group(45 cases).The control group was treated with non-invasive ventilator,and the study group was treated with salbutamol on this basis.Respiratory function indexes,serum inflammatory factors and adverse reactions were compared between the two groups.Results After 1 week of treatment,the blood partial carbon dioxide pressure(PaCO_(2))of the study group(40.60±3.28)mmHg was lower than that of the control group(46.50±4.03)mmHg.Arterial partial oxygen pressure(PaO_(2))index(96.66±4.87)mmHg,PaO_(2)/inhaled oxygen concentration(367.72±9.55)mmHg were higher than those in the control group(89.80±5.95)mmHg and(355.22±8.85)mmHg,the difference was statistically significant(t=7.583,5.958,6.401,P<0.05).After 1 week of treatment,the indexes of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the study group were lower than those in the control group,the difference was statistically significant(P<0.05).There was no statistically significance in the incidence of adverse reaction between the two groups(P>0.05).Conclusion The treatment effect of noninvasive ventilator combined with salbutamol for COPD complicated with RF is exact,which can effectively improve respiratory function and inhibit inflammatory factors.