伏立康唑治疗对肺部侵袭性真菌感染患者肺功能的影响

Effect of Voriconazole Treatment on Lung Function in Patients with Pulmonary Invasive Fungal Infection

目的分析伏立康唑治疗对肺部侵袭性真菌感染(invasive pulmonary fungal infection,IPFI)患者肺功能的影响。方法选取2021年7月—2022年12月盐城市第一人民医院收治的60例肺部IPFI患者为研究对象,按照信封法分为两组,对照组(n=30)给予常规治疗,观察组(n=30)另加用伏立康唑治疗,对比两组治疗效果、肺功能、炎症因子及不良反应发生情况。结果观察组治疗有效率96.67%高于对照组的73.33%,差异有统计学意义(χ^(2)=4.706,P=0.030)。治疗后,观察组的肺功能指标、炎症因子指标均优于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论对肺部IPFI患者采取伏立康唑治疗,可显著减轻患者不适症状和炎症状态,改善其肺功能,且不良反应发生率较低。

Objective Analyze the effect of voriconazole treatment on lung function in patients with invasive pulmonary fungal infection(IPFI).Methods 60 patients with pulmonary IPFI admitted to the First People′s Hospital of Yancheng City from July 2021 to December 2022 were selected as the study subjects.They were divided into two groups according to the envelope method.The control group(n=30)received routine treatment,while the observation group(n=30)received additional treatment with voriconazole.The treatment effects,lung function,inflammatory factors,and adverse reactions of the two groups were compared.Results The effective rate of treatment in the observation group was 96.67%,which was higher than 73.33%in the control group,the difference was statistically significant(χ^(2 )=4.706,P=0.030).After treatment,the lung function indicators and inflammatory factor indicators in the observation group were better than those in the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The treatment of pulmonary IPFI patients with voriconazole can significantly reduce discomfort symptoms and inflammatory status,improve lung function,and have a lower incidence of adverse reactions.