屈螺酮炔雌醇片联合二甲双胍治疗多囊卵巢综合征的临床观察

Clinical observation of drospirenone ethinylestradiol tablets combined with metformin in the treatment of polycystic ovarysyndrome

目的分析屈螺酮炔雌醇片联合二甲双胍治疗多囊卵巢综合征(PCOS)的应用效果。方法选取60例PCOS患者,按照随机排列表法分为对照组(使用屈螺酮炔雌醇片治疗)与联合组(使用屈螺酮炔雌醇片+二甲双胍治疗),每组30例。比较两组患者的内分泌激素水平、体质量指数(BMI)与胰岛素水平。结果治疗前,两组患者的促黄体生成素(LH)、卵泡刺激素(FSH)、睾酮(T)水平比较,差异无统计学意义(P>0.05);治疗后,两组患者FSH水平比较,差异无统计学意义(P>0.05),联合组LH、T水平低于对照组(P<0.05)。治疗前,两组患者BMI、空腹胰岛素(FIN)与胰岛素抵抗指数(HOMA-IR)水平比较,差异无统计学意义(P>0.05);治疗后,联合组BMI、FIN和HOMA-IR水平均低于对照组(P<0.05)。结论屈螺酮炔雌醇片联合二甲双胍有助于改善PCOS患者的内分泌激素水平,降低患者的BMI与胰岛素水平。

Objective To analyze the effect of drospirenone ethinylestradiol tablets combined with metformin in the treatment of polycystic ovary syndrome(PCOS).Methods 60 patients with PCOS were selected and divided into control group(treated with drospirone ethinylestradiol tablets)and combination group(treated with drospirone ethinylestradiol tablets+metformin)according to random arrangement table method,with 30 cases in each group.Endocrine hormone levels,body mass index(BMI)and insulin levels were compared between the two groups.Results Before treatment,there was no significant difference in the levels of luteinizing hormone(LH),follicle-stimulating hormone(FSH)and testosterone(T)between 2 groups(P>0.05).After treatment,there was no significant difference in FSH levels between two groups(P>0.05),LH and T levels in combination group were lower than those in control group(P<0.05).Before treatment,there was no significant difference in BMI,fasting insulin(FIN)and insulin resistance index(HOMA-IR)between the two groups(P>0.05).After treatment,BMI,FIN and HOMA-IR levels in combination group were lower than those in control group(P<o.05).Conclusion Drospirenone ethinylestradiol tablets combined with metformin can improve endocrine hormone levels and reduce BMI and insulin levels in patients with PCOS.