黄酮类化合物纳米晶体的制备及应用研究进展

Research progress on the preparation and application of flavonoid nanocrystals

黄酮类化合物具有抗氧化、抗炎、抗癌等多种药理作用,但由于其溶解度低、生物利用度较低,临床应用受到了极大限制。纳米晶体技术可通过降低难溶性黄酮类化合物的粒径,显著增加其溶出度,改善其生物利用度,从而解决黄酮类化合物的递送困难。本文概括了黄酮类化合物纳米晶体稳定剂的筛选与制备方法,并对黄酮类化合物纳米晶体应用于口服、注射、经皮等多种给药途径进行综述,以期为黄酮类化合物纳米晶体递送系统的进一步研究提供参考。

Flavonoids have been reported to possess significant pharmacological activities,such as antioxidant,anti-inflammatory and anticancer effects.However,the low solubility and low bioavailability limits their clinical application.Nanocrystal technology can solve the delivery problems of flavonoids by reducing particle size,increasing the solubility of insoluble drugs and improving their bioavailability.This article summaries nanosuspension preparation methods and the stabilizers for flavonoid nanocrystals,and reviews the drug delivery routes including oral,Injection and transdermal of flavonoid nanocrystals,to provide information for further research on nanocrystal delivery system of flavonoids.