摘要
Lipid is a key component of plasma membrane,which plays an important role in the regulation of various cell biological behaviors,including cell proliferation,growth,differentiation and intracellular signal transduction.Studies have shown that abnormal lipid metabolism is involved in many malignant processes,including colorectal cancer(CRC).Lipid metabolism in CRC cells can be regulated not only by intracellular signals,but also by various components in the tumor microenvironment,including various cells,cytokines,DNA,RNA,and nutrients including lipids.In contrast,abnormal lipid metabolism provides energy and nutrition support for abnormal malignant growth and distal metastasis of CRC cells.In this review,we highlight the remodeling roles of lipid metabolism crosstalk between the CRC cells and the components of tumor microenvironment.
基金
supported by the National Natural Science Foundation of China(Nos.31800658 and 82072218)
Henan Province Young and Middle-Aged Health Science and Technology Innovation Talent Project(No.YXKC2021044)
Joint Construction Project of Henan Medical Science and Technology Research Plan(No.LHGJ20200504)
Teaching and Research Cultivation Project of School of Basic Medical Sciences,Xinxiang Medical College(No.JCYXYKY202021).
